T. Zhao

TMEM33 deletion potentiates anti-tumor CD8+ T cell immunity

This study shows TMEM33 limits progenitor-exhausted CD8+ T cells, enhances anti-tumor responses, and correlates with improved survival in melanoma patients.

An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer

The paper develops a co-culture model of lung cancer organoids and peripheral blood mononuclear cells to study systemic anti-tumor immunity and predict immunotherapy outcomes.

Amidase and Lysozyme Dual Functions in TseP Reveal a New Family of Chimeric Effectors in the Type VI Secretion System

This paper identifies TseP as a dual amidase-lysozyme T6SS effector with potential for combating antimicrobial resistance.

CREEPING STEM1 Regulates Directional Auxin Transport for Lodging Resistance in Soybean

This study identifies the CS1 gene in soybean, which regulates directional auxin transport and enhances lodging resistance, improving yield under high planting density.

Isolation and characterization of three lytic podo-bacteriophages with two receptor recognition modules against multidrug-resistant Klebsiella pneumoniae

The paper isolates and characterizes three lytic bacteriophages against multidrug-resistant K. pneumoniae, identifying receptor recognition modules and infection mechanisms.

Metabolic Vulnerabilities of Temozolomide-Resistant Glioblastoma Cells: Implications for Targeted Therapies and Overcoming Chemoresistance

The paper identifies metabolic vulnerabilities in TMZ-resistant glioblastoma cells, showing that iron reduction enhances the efficacy of TMZ through mechanisms involving Hif1, autophagy, and ROS.

Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically "actionable" signalling axis in triple negative breast cancer

This study identifies a novel feed-forward signalling axis between PEAK1 and CAMK2 in TNBC, showing that targeting CAMK2 can inhibit PEAK1-driven oncogenic processes.

Biological management, rather than chemical management, promotes the interaction between plants and their microbiome

This study identifies potato cultivars that promote beneficial interactions with rhizosphere microbes under biological management, showing that plant cultivar and microbiome together influence below-ground growth, unlike under chemical management.

Function-associated scRNA-seq on single lung cancer organoids unravels the immune landscape of tumor parenchyma

The paper uses single-cell RNA sequencing on lung cancer organoids to study the tumor immune microenvironment and identifies key genes and T cell activity factors related to immunotherapy response.

Connecting Chromatin Structures to Gene Regulation Using Dynamic Polymer Simulations

The paper uses polymer simulations to model chromatin dynamics and shows that productive interactions depend on contact frequency, capture radius, and duration, not just average contact matrices.

SARS-CoV-2 Omicron infection augments the magnitude and durability of systemic and mucosal immunity in triple-dose CoronaVac recipients

This study examines immune responses in CoronaVac-vaccinated individuals after Omicron infection, showing enhanced antibody and cellular immunity compared to unvaccinated controls.

Nifuroxazide Suppresses PD-L1 Expression and Enhances the Efficacy of Radiotherapy in Hepatocellular Carcinoma

This study shows nifuroxazide enhances radiotherapy in HCC by reducing PD-L1 expression and improving tumor response.

Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

This study compares a novel VZV mRNA vaccine (ZOSAL) with Shingrix in mice and rhesus macaques, showing ZOSAL induces stronger T cell immunity and safety.

Sub-nucleolar trafficking of Hendra virus matrix protein is regulated by ubiquitination and oligomerisation

This study identifies ubiquitination and oligomerisation as mechanisms regulating Hendra virus matrix protein trafficking between sub-nucleolar compartments.

Optogenetic strategies for optimizing the performance of biosensors of membrane phospholipids in live cells

This paper presents optogenetic strategies to enhance phospholipid biosensors in live cells by reducing background signals and amplifying detection through light-controlled probe release and phase separation.

Unbiased phosphoproteomics analysis unveils modulation of insulin signaling by extramitotic CDK1 kinase activity in human myotubes

The paper uses phosphoproteomics to show that CDK1 activity modulates insulin signaling and glucose uptake in human myotubes, with group-specific phosphorylation changes observed.

Resolving the developmental mechanisms of coagulation abnormalities characteristic of SARS-CoV2 based on single-cell transcriptome analysis

This study uses single-cell transcriptome analysis to identify immune and metabolic mechanisms underlying coagulation abnormalities in SARS-CoV-2 infection.

SunTag-PE: a modular prime editing system enables versatile and efficient genome editing

The paper introduces a modular prime editing system called SunTag-PE that improves delivery efficiency without compromising editing efficiency.

Thymic mesenchymal niche cells drive T cell immune regeneration

This study identifies a thymic mesenchymal niche cell subset that supports T cell regeneration and shows its therapeutic potential in reversing thymic atrophy.

Allostery in STAT3 Variant D170A is Mediated by a Rigid Core

This paper investigates the allosteric mechanism of STAT3 variant D170A, showing that the coiled-coil domain regulates SH2 domain conformation through a rigid core.

Ralstonia solanacearum effector RipAF1 ADP-ribosylates host FBN1 to induce resistance against bacterial wilt

This study identifies RipAF1 as an effector that ADP-ribosylates host FBN1, inducing resistance against bacterial wilt by disrupting disease signaling.

Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events

This study identifies multiple recombination events between SARS-CoV-2 Omicron subvariants and other variants, suggesting co-infection and recombination drive viral evolution.

Complete sequences of the velvet worm slime proteins reveal that slime formation is enabled by disulfide bonds and intrinsically disordered regions

The paper determines the complete sequences of velvet worm slime proteins and identifies disulfide bonds and intrinsically disordered regions as key to slime self-assembly.

Hypoxia Dynamically Regulates DBC1 Ubiquitination and Stability by SIAH2 and OTUD5 in Breast Cancer Progression

This study identifies hypoxia-regulated ubiquitination of DBC1 by SIAH2 and OTUD5 as a mechanism driving breast cancer progression.

New insights into colorectal cancer liver metastasis carcinogenesis and its effect with moxibustion

This study investigates the effect of moxibustion on colorectal cancer liver metastasis using animal models, finding reduced metastasis rates and identifying potential molecular targets.

Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination

This study shows Senataxin and RNase H2 work together to remove R loops and prevent genome instability during class switch recombination.

Large-scale miRNA-Target Data Analysis to Discover miRNA Co-regulation Network of Abiotic Stress Tolerance in Soybeans

The paper uses computational methods to predict miRNA-target regulatory modules in soybeans under abiotic stress and identifies stress-related modules with gene ontology enrichment.

Bioimage postprocessing based on discrete wavelet transform and Lucy-Richardson deconvolution methods

This paper improves image resolution and signal-to-noise ratio in live cell imaging using a combination of discrete wavelet transform and Lucy-Richardson deconvolution.

Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine

This paper shows that oxidative phosphorylation (OXPHOS) generates most ATP in mouse ESCs and is essential for pluripotency by coupling with the hexosamine biosynthesis pathway to produce UDP-GlcNAc.

Bark beetles locate fungal symbionts by detecting volatile fungal metabolites of host tree resin monoterpenes

This study shows bark beetles use volatile oxygenated metabolites from fungal symbionts to locate breeding sites with beneficial fungi.