Author

T. Saunders

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. Ginsburg· 2 shared R. Khoriaty· 2 shared A. Bernard· 1 shared A. C. Weyand· 1 shared A. Kuppa· 1 shared A. Nesvizhskii· 1 shared A. Pal· 1 shared A. Pant· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

D. Ginsburg

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6 papers

Recent·Most cited

Asynchronous microexon splicing of LSD1 and PHF21A during neurodevelopment

M. Nagai, R. S. Porter, E. Hughes, T. Saunders, S. Iwase

The paper shows that PHF21A microexon expression precedes LSD1 microexon expression during neurodevelopment, leading to stepwise deactivation of the LSD1-PHF21A complex and unique gene-regulatory roles in neurons.

bioRxiv · Mar 21, 2024Biochemistry

Development of a major histocompatibility complex class II conditional knockout mouse to study cell-specific and time-dependent adaptive immune responses in peripheral nerves.

E. Ubogu, J. Conner, Y. Wang, D. Yadav, T. Saunders

This paper develops a conditional MHC class II knockout mouse to study cell-specific and time-dependent adaptive immune responses in peripheral nerves, showing resistance to autoimmune neuropathy despite MHC class II expression.

bioRxiv · Jul 24, 2023Immunology

Knockout of murine Lyplal1 confers sex-specific protection against diet-induced obesity

R. B. Vohnoutka, A. Kuppa, Y. Hegde, Y. Chen, A. Pant, E.-Y. K. Choi, S. M. McCarty, D. Bagchi, X. Du, Y. Chen, V. L. Chen, L. F. Bielak, L. H. Maguire, S. K. Handelman, J. Z. Sexton, , E. K. Speliotes

This study shows that knocking out Lyplal1 in mice leads to sex-specific protection against diet-induced obesity, mirroring human genetic findings.

bioRxiv · Aug 5, 2021Biochemistry

Mitochondrial Complex II In Intestinal Epithelial Cells Regulates T-cell Mediated Immunopathology

H. Fujiwara, A. V. Mathew, I. Kovalneko, A. Pal, H.-J. Lee, D. Peltier, S. Kim, C. Liu, K. Oravecz-Wilson, L. Li, Y. Sun, J. Byun, T. Saunders, A. Rehemtulla, C. A. Lyssiotis, , P. Reddy

This study identifies mitochondrial complex II disruption in intestinal epithelial cells as a key driver of T-cell mediated intestinal immunopathology across multiple disease models.

bioRxiv · Mar 12, 2020Immunology

Murine Surf4 is essential for early embryonic development

B. T. Emmer, P. J. Lascuna, E. Kotnik, T. Saunders, R. Khoriaty, D. Ginsburg

This study shows that Surf4 is essential for early embryonic development in mice, as Surf4-/- embryos die between E3.5 and E9.5, while Surf4+/- mice are normal.

bioRxiv · Feb 7, 2019Cell Biology

The Function of the COPII Gene Paralogs SEC23A and SEC23B Are Interchangeable In Vivo

R. Khoriaty, G. Hesketh, A. Bernard, A. C. Weyand, D. Mellacheruvu, G. Zhu, M. J. Hoenerhoff, B. McGee, L. Everett, E. J. Adams, B. Zhang, T. Saunders, A. Nesvizhskii, D. J. Klionsky, J. A. Shavit, , D. Ginsburg

This study shows SEC23A and SEC23B are functionally interchangeable in vivo, suggesting phenotypic differences arise from gene expression rather than protein function.

bioRxiv · Nov 7, 2017Evolutionary Biology