Author

S. Ko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 2 Pathology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 7 Approach:experimental assay· 6 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

A. Singhi· 4 shared S. Hu· 4 shared A. Bell· 3 shared J. Tao· 3 shared K. Nejak-Bowen· 3 shared M. Poddar· 3 shared S. Liu· 3 shared S. P. Monga· 3 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

A. Singhi

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Therapeutic potential of SOX9 dysruption in Combined Hepatocellular Carcinoma-Cholangiocarcinoma

Y. Park, S. Hu, M. Kim, M. Oertel, A. Singhi, S. P. Monga, S. Liu, S. Ko

This study contrasts the effects of developmental and acute Sox9 deletion in cHCC-CCA models, showing that Sox9 elimination can reduce tumor burden and highlights therapeutic potential.

bioRxiv · May 22, 2024Cancer Biology

A single-cell atlas of the aging murine ovary

J. Isola, S. R. Ocanas, C. Hubbart, S. Ko, S. Ali Mondal, J. Hense, H. N. C. Carter, A. Schneider, S. Kovats, J. Alberola-Ila, W. M. Freeman, M. Stout

This study creates a single-cell RNA sequencing atlas of aging mouse ovaries, identifying immune cell expansion, collagenase pathway downregulation, and stress/fibrotic signaling in follicular cells.

bioRxiv · Apr 29, 2023 · PreprintCell Biology

Mature microRNA-binding protein QKI promotes microRNA-mediated gene silencing

J.-H. Yoon, K.-W. Min, M. H. Jo, M. Song, S. Ko, J. W. Lee, M. J. Shim, K. Kim, H. B. Park, S. Ha, H. Mun, A. Polash, M. Hafner, J.-H. Cho, D.-S. Kim, , S.-U. Kang

The paper identifies QKI as a novel microRNA-binding protein that enhances AGO2/let-7b-mediated gene silencing and suppresses tumor growth.

bioRxiv · Mar 15, 2023Biochemistry

Label-free adaptive optics single-molecule localization microscopy for whole animals

S. Park, Y. Jo, M. Kang, J. H. Hong, S. Ko, S. Kim, S. Park, H.-C. Park, S.-H. Shim, W. Choi

This paper develops a label-free adaptive optics method for SMLM, enabling deep-tissue super-resolution imaging in whole animals by correcting tissue aberrations.

bioRxiv · Nov 18, 2021 · PreprintBiophysics

β-Catenin-NFκB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction

S. Hu, J. Russell, S. Liu, R. Rai, K. Kosar, J. Tao, E. Hurley, M. Poddar, S. Singh, A. Bell, D. Shin, R. Raeman, A. Singhi, K. Nejak-Bowen, S. ko, S. P Monga

This study identifies a β-catenin-NFκB-CFTR interactome in cholangiocytes that regulates inflammation and fibrosis during ductular reaction in liver disease.

eLife · Oct 5, 2021Peer-reviewedPathology

NOTCH-YAP1/TEAD-DNMT1 axis regulates hepatocytereprogramming into intrahepatic cholangiocarcinoma

S. Hu, L. M. Molina, J. Tao, S. Liu, M. Hassan, S. Singh, M. Poddar, A. Bell, D. Sia, M. Oertel, R. Raeman, K. Nejak-Bowen, A. Singhi, J. Luo, S. P. Monga, S. Ko

The paper identifies a NOTCH-YAP1/TEAD-DNMT1 axis that drives hepatocyte reprogramming into intrahepatic cholangiocarcinoma and reveals its role in tumor development.

bioRxiv · Dec 3, 2020 · PreprintCancer Biology

Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors

L. M. Molina, J. Zhu, Q. Li, T. Pradhan-Sundd, K. Sayed, N. Jenkins, R. Vats, S. Ko, S. Hu, M. Poddar, S. Singh, J. Tao, P. Sundd, A. Singhi, S. C. Watkins, , S. P. Monga

This study shows YAP1 is essential for bile duct development and reveals hepatocyte adaptation in its absence.

bioRxiv · Oct 21, 2020Pathology

A metastable contact and structural disorder in the estrogen receptor transactivation domain

Y. Peng, S. Cao, J. Kiselar, X. Xiao, Z. Du, A. Hsien, S. Ko, Y. Chen, P. Agrawal, W. Zheng, W. Shi, W. Jiang, L. Yang, M. Chance, W. Surewicz, , S. Yang

This study investigates the structure and function of the estrogen receptor alpha N-terminal domain using multiple techniques, revealing metastable contacts and their role in transactivation.

bioRxiv · Oct 8, 2018Biophysics