AMPK targets PDZD8 to trigger carbon source shift to glutamine
M. Li, Y. Wang, X. Wei, W.-F. Cai, M. Zhu, L. Yao, Y. Wang, Y.-H. Liu, J. Wu, J. Xiong, X. Tian, Q. Qu, R. Xie, X. Li, S. Chen, , S.-C. Lin
This paper identifies AMPK's role in shifting carbon utilization from glucose to glutamine via PDZD8 phosphorylation, enhancing glutaminolysis and extending lifespan in C. elegans and mice.
bioRxiv · Jul 20, 2023 · PreprintCell Biology