Author

S.-C. Lin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Physiology· 2 Animal Behavior & Cognition· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:proteomics· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 3 Organism:C. elegans· 2

Frequent Co-Authors

C. Zhang· 4 shared C.-S. Zhang· 4 shared H.-l. Piao· 4 shared B. Zhang· 3 shared J. Wu· 3 shared M. Li· 3 shared M. Zhu· 3 shared Q. Qu· 3 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersPhysiology

C. Zhang

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Lithocholic acid phenocopies rejuvenating and life-extending effects of calorie restriction

Q. Qu, Y. Chen, Y. Wang, S. Long, W. Wang, H.-Y. Yang, M. Li, X. Tian, X. Wei, Y.-H. Liu, S. Xu, C. Zhang, M. Zhu, S. M. Lam, J. Wu, , S.-C. Lin

This study identifies lithocholic acid as a metabolite that mimics calorie restriction's anti-aging effects in multiple species through AMPK activation.

bioRxiv · Dec 7, 2023 · PreprintPhysiology

Lithocholic acid targets TULP3 to activate sirtuins and AMPK to retard ageing

Q. Qu, Y. Chen, Y. Wang, S. Long, W. Wang, H.-Y. Yang, J. Wu, M. Li, X. Tian, X. Wei, Y.-H. Liu, S. Xu, C. Yang, Z. Wu, X. Huang, , Y. Yu

This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.

bioRxiv · Dec 7, 2023 · PreprintPhysiology

Probucol mitigates high-fat diet-induced cognitive and social impairments through disruption of redox-inflammation association

H.-M. Wu, N.-J. Huang, Y. V. Yang, L.-P. Fan, T.-Y. Tang, L. Liu, Y. Xu, D.-T. Liu, Z.-X. Cai, X.-Y. Ren, Z.-H. Yao, J.-Z. Chen, X. Huang, C. Zhang, X. You, , S.-Y. Lin

This study shows probucol reduces high-fat diet-induced cognitive and social impairments in mice without affecting obesity or metabolic homeostasis, by disrupting redox-inflammation links.

bioRxiv · Sep 5, 2023Animal Behavior & Cognition

AMPK targets PDZD8 to trigger carbon source shift to glutamine

M. Li, Y. Wang, X. Wei, W.-F. Cai, M. Zhu, L. Yao, Y. Wang, Y.-H. Liu, J. Wu, J. Xiong, X. Tian, Q. Qu, R. Xie, X. Li, S. Chen, , S.-C. Lin

This paper identifies AMPK's role in shifting carbon utilization from glucose to glutamine via PDZD8 phosphorylation, enhancing glutaminolysis and extending lifespan in C. elegans and mice.

bioRxiv · Jul 20, 2023 · PreprintCell Biology

RK-33, a small molecule inhibitor of host RNA helicase DDX3, suppresses multiple variants of SARS-CoV-2

F. Vesuna, I. Akhrymuk, A. Smith, P. T. Winnard, S.-C. Lin, R. Scharpf, K. Kehn-Hall, V. Raman

This study shows that RK-33, a DDX3 inhibitor, reduces SARS-CoV-2 viral load across multiple variants in Calu-3 cells and downregulates SARS-CoV-2 genes and TMPRSS2 expression.

bioRxiv · Feb 28, 2022Microbiology

Activation of retinoic acid receptor reduces metastatic prostate cancer bone lesions through blocking endothelial-to-osteoblast transition

G. Yu, P. G. Corn, P. Shen, J. H. Song, Y.-C. Lee, S.-C. Lin, J. Pan, S. K. Agarwal, T. Panaretakis, M. Pacifici, C. J. Logothetis, L.-y. Yu-Lee, S.-H. Lin

bioRxiv · Dec 22, 2021Cancer Biology

Prostate tumor-induced stromal reprogramming generates Tenascin C that promotes prostate cancer metastasis through YAP/TAZ inhibition

S.-H. Lin, Y.-C. Lee, S.-C. Lin, G. Yu, M. Zhu, J. H. Song, K. Rivera, D. J. Pappin, C. J. Logothetis, T. Panaretakis, G. Wang, L.-y. Yu-Lee

This study shows that prostate tumor-induced stromal reprogramming produces Tenascin C, which promotes metastasis by inhibiting YAP/TAZ through 5{beta}1 integrin.

bioRxiv · Nov 8, 2021Cancer Biology

Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex

T. Xia, D. Chen, X. Liu, H. Qi, W. Wang, H. Chen, T. Ling, W. Otkur, C.-S. Zhang, J. Kim, S.-C. Lin, H.-l. Piao

This study shows that Midkine suppresses AMPK activation by disrupting the LKB1-STRAD-Mo25 complex, promoting cancer cell proliferation and correlating with poor clinical outcomes in specific cancers.

bioRxiv · Sep 27, 2021Cancer Biology