H. Long

Structural basis of bulk lipid transfer by bridge-like lipid transfer protein LPD-3

This study determines the structure of the LPD-3 BLTP complex and reveals its mechanism for bulk lipid transfer through interactions with Intake and Spigot proteins.

A standalone reverse dissimilatory sulfite reductase (rDsr) pathway enables sulfur oxidation under oxygen limitation

This study shows that the reverse dissimilatory sulfite reductase (rDsr) pathway can independently oxidize thiosulfate under low oxygen conditions, supporting its ecological role in marine sediments.

Increased chromatin accessibility mediated by nuclear factor I drives transition to androgen receptor splice variant dependence in castration-resistant prostate cancer

This study shows that ARv7 drives AR activity in castration-resistant prostate cancer through increased chromatin accessibility mediated by NFI factors.

Single-cell Sequencing Highlights Heterogeneity and Malignant Progression in Actinic Keratosis and Cutaneous Squamous Cell Carcinoma

This study uses single-cell RNA-seq to analyze the progression from actinic keratosis to cutaneous squamous cell carcinoma, identifying key driver genes and tumor microenvironment interactions.

Breast cancer cells can recognize and respond to different levels of progestins to achieve different phenotypic outputs

This study shows that breast cancer cells respond differently to low and high levels of progestins, with low levels promoting proliferation through specific molecular mechanisms.

HOXB13 alters chromatin accessibility in prostate cancer through interactions with the SWI/SNF complex

This study shows HOXB13 promotes prostate cancer proliferation by altering chromatin accessibility through interactions with the SWI/SNF complex, particularly in AR-negative castration-resistant prostate cancer.

Primordial germ cells adjust their protrusion type while migrating in different tissue contexts in vivo

This study shows zebrafish primordial germ cells change their protrusion type and blebbing behavior depending on the tissue environment, maintaining motility parameters through adjustments in RhoA activity and cortical tension.

Robust SARS-CoV-2-specific T-cell immunity is maintained at 6 months following primary infection

This study shows that SARS-CoV-2-specific T-cell immunity remains robust six months after infection, with response magnitude linked to initial infection severity.

A non-canonical EZH2 function sensitizes solid tumors to genotoxic stress

This study shows EZH2 inhibitors inhibit CRPC growth by downregulating DNA repair genes, making cancer cells more sensitive to genotoxic stress.

Susceptibility of tree shrew to SARS-CoV-2 infection

This study investigates tree shrew susceptibility to SARS-CoV-2 infection and finds that they show mild symptoms and low viral replication, suggesting limited susceptibility.

Parkinson's disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM

The paper determines the cryo-EM structure of phosphorylated α-synuclein fibrils at Tyr39, revealing structural changes linked to Parkinson's disease pathology.

Comparison of SARS-CoV-2 infections among 3 species of non-human primates

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

Parkinson's disease associated mutation E46K of α-synuclein triggers the formation of a novel fibril structure

This study determines the cryo-EM structure of a novel α-synuclein fibril formed by the E46K mutation, showing structural changes and altered stability compared to wild-type fibrils.

Predicting master transcription factors from pan-cancer expression data

This paper introduces CaCTS, an algorithm that identifies candidate master transcription factors (MTFs) across 34 cancer types using RNA-seq data, revealing novel MTFs and functional groupings.

Mechanistic insights into NAD synthase NMNAT chaperoning phosphorylated Tau from pathological aggregation

This study identifies NMNAT as a chaperone that prevents phosphorylated Tau aggregation in vitro and reduces pathology in a fly model.

An abscisic acid (ABA) homeostasis regulated by its production, catabolism and transport in peanut leaves in response to drought stress

This study identifies and analyzes genes involved in ABA production, catabolism, and transport in peanut leaves under drought stress, showing their coordinated regulation of ABA homeostasis.