comparative / phylogenetic analysis

The paper identifies hyper/hypocalcemia-causing mutations in the Calcium-Sensing Receptor by analyzing its evolutionary history and using phylogenetic methods and gradient-boosting trees.

The paper examines gene family evolution in Brassicaceae-feeding lepidopterans to understand how detoxification and sensory genes relate to host plant range specialization.

This paper identifies conserved ribosome-binding mechanisms in β-coronavirus Nsp1 proteins and shows how a cis-acting RNA element modulates Nsp1 function.

The paper investigates the evolutionary history of ABC transporters and UGTs in Archaeplastida, showing their ancient origins and diversification, with UGTs appearing later in streptophyte lineages.

The paper compares LPS-induced transcriptional responses in white-footed deermice, mice, and rats, finding reduced interferon responses and alternative macrophage activation in deermice.

The paper identifies convergent evolution and accelerated positive selection of vesicle-associated RhoGAP proteins in two parasitoid wasp species, showing loss of GAP activity and GTPase binding.

The paper compares co-evolutionary lineages of gut microbes in wild primates and humans, revealing opposing health implications of specific microbial traits.

The paper compares amygdala volume evolution in domesticated and cooperatively breeding mammals, finding convergent increases in the lateral nucleus linked to reduced fear aggression, with humans showing additional prosocial traits.

The paper investigates the evolutionary origins of bacterial glycyl tRNA synthetase (bacGlyRS) and its relationship to alanyl tRNA synthetase, finding common ancestral domains and suggesting a stepwise domain accumulation process.

This study shows that circadian-driven sleep is conserved across Drosophila species, but homeostatic regulation of sleep varies and evolved independently.

The paper investigates the origin of duplicated homeobox genes in spiders, finding most are from a whole genome duplication, with evidence of subfunctionalisation in the NK cluster.

This study uses comparative transcriptomics to show that acoustic fat bodies in toothed whales evolved from skull muscles through a trade-off involving fatty acid metabolism and tissue reorganization.

The paper shows that true passerines lost the ghrelin gene but retain its receptor, suggesting a replacement ligand for migratory fat accumulation.

This study investigates the origin and evolution of the chemokine system, revealing independent evolution of chemokine-like functions and vertebrate-specific receptor origins.

The paper investigates domain rearrangements in termite proteomes to understand their role in the evolution of eusociality, finding novel arrangements linked to longevity and caste-specific functions.

This study compares the biochemical and biological potencies of three EP300/CREBBP acetyltransferase inhibitors and demonstrates their utility in investigating epigenetic mechanisms.

The paper investigates mitotic strategies in Ichthyosporea, showing divergence towards fungal-like closed or animal-like open mitosis, with multinucleated life cycles favoring closed mitosis.

This study shows that songbirds avoid oxidative stress from high blood glucose at the macroevolutionary level, despite within-species oxidative costs.

This study investigates the evolution of piRNA clusters in Drosophila melanogaster by comparing piC activity and sequence composition across strains, supporting both de novo and trap models of piC formation.

The paper investigates how cell density and mechanical constraints influence epithelial architecture transitions, showing that crowding drives the first transition and adhesion drives the second.

This study analyzes the evolutionary patterns of regulatory and coding sequences in opium poppy following whole-genome duplication, showing rapid regulatory element evolution contributes to new phenotypes.

This study analyzes Klebsiella isolates from the International Space Station, revealing emerging pathogenic lineages with resistance genes and potential for horizontal gene transfer.

This study maps molecular differences in vesicle formation machinery between Giardia intestinalis assemblages A and B using genomic analysis of 89 isolates.

This paper examines the biogeography and evolutionary history of lunulite bryozoans, highlighting convergent evolution and distinct patterns in Western Australia.

The paper identifies a new ecospecies of Helicobacter pylori, 'Hardy', found in Indigenous populations and animal-adapted lineages, with distinct genetic features and evolutionary history.

This paper presents the first chromosome-scale genome assemblies of American hazelnut, enabling structural variation analysis and phylogenetic studies of self-incompatibility in the Corylus genus.

A 240-species placental mammal alignment resolves constraint to single bases, estimating at least 10.7% of the human genome is constrained, with 48.5% of constrained bases unannotated.

This study identifies a farnesyl-dependent structural role for CENP-E in fibrous corona expansion during mitosis, independent of its motor activity.

This study shows that microbial symbionts, particularly Endozoicomonas, influence coral growth and disease susceptibility across 425 million years of evolution.

This study compares antiviral responses in two bat species, finding conserved gene upregulation and divergent transcriptional patterns linked to viral tolerance and resistance.