Mitochondrial Function and Pathology

The paper uses cryo-STET to study mitochondrial fission in MFF mutant cells under ATP-depleting conditions, revealing fission progression without MFF.

This study uses in vivo 2-photon imaging and photoactivatable fluorescent labeling to show that mitochondrial dynamics in skeletal muscle are slower in vivo than previously thought, with age-related differences and exercise-induced increases.

This study shows that increased mitochondrial membrane potential causes nuclear DNA hypermethylation, which affects gene expression related to mitochondria and lipid metabolism through phospholipid remodeling.

This study characterizes bioenergetic and glycolytic profiles in three cardiomyocyte models, revealing distinct metabolic adaptations in mouse adult cardiomyocytes.

The paper identifies genes regulating mitochondrial fission in C. elegans and shows that chromosome missegregation leads to mitochondrial fission dysregulation, independent of Drp-1.

This study investigates age-related changes in mitochondrial 3D structure in human skeletal muscle and shows that exercise can restore mitochondrial integrity through mitofusin 2.

This study investigates VDAC2's conformational flexibility and its impact on interactions with cytosolic proteins like α-synuclein, revealing kinetic differences without altering binding affinity.

This study shows mitochondrial stress triggers PKCδ activation and Lamin B1 phosphorylation, leading to nuclear membrane damage and neuronal cell death in Parkinson's disease.

This study identifies FKBP8 as the tethering partner of PDZD8 at ER-mitochondria contact sites, showing their interdependence in regulating mitochondrial morphology.

The paper shows that mitochondrial morphology in yeast is controlled by the redox state, not mitochondrial activity, and demonstrates reversible control through metabolic changes.

The study shows the Y951N mutation in POLgamma impairs its ability to switch between DNA synthesis and degradation, causing mtDNA depletion without directly affecting polymerase or exonuclease activity.

This study uses zebrafish atad3 knockout models to identify mitochondrial dysfunction as a key mechanism in ATAD3A-related human diseases.

This study identifies a bioenergetic mechanism in AML cells where mitochondria consume ATP to resist chemotherapy, offering a target for improving treatment.

This study identifies TMEM65 as a regulator of NCLX-dependent mitochondrial calcium efflux, showing its role in preventing calcium overload and cell death in excitable tissues.

This study identifies Atf3 as a key regulator of transition from compensation to dysfunction in female mitochondrial cardiomyopathy using single-cell transcriptomics.

This study determines the structure of Drp1 on lipid membranes, revealing a locally ordered lattice and conformational changes that suggest a ratchet mechanism for mitochondrial constriction.

The paper identifies a novel MFN2 variant, Q367H, linked to mtDNA-mediated inflammation in a patient with distal myopathy, revealing a pathomechanism connecting MFN2 dysfunction to inflammatory signaling.

The paper examines mitochondrial distribution patterns across tissues and finds they lack coherence, suggesting tissue-specific and individualized regulatory mechanisms.

This study identifies Mpf1 as a novel factor influencing the dual targeting of tail-anchored proteins between mitochondria and peroxisomes in yeast.

This study identifies three factors contributing to MCUB-dependent inhibition of mitochondrial calcium uptake using cell lines and live-cell imaging.

This study shows that endothelial MICU1 prevents vascular inflammation and atherosclerosis by maintaining mitochondrial calcium homeostasis and reducing mitochondrial reactive oxygen species.

This study shows that oxidative injury to mitochondrial DNA contributes to acute and chronic lung injury, and that targeting OGG1 can mitigate this damage.

The paper creates a brain-wide map of mitochondrial phenotypes by combining physical voxelization with biochemical profiling, revealing regional differences in mitochondrial density and function.

This study determines the molecular organisation of the human prohibitin complex within the mitochondrial inner membrane using structural biology methods.

This study shows that chronic hydrogen sulfide exposure alters mitochondrial structure and function in human cells by disrupting cristae and respiratory supercomplexes.

The paper uses cryo-electron tomography to visualize mitochondrial respiratory complexes in Chlamydomonas reinhardtii, revealing their organization into distinct membrane domains and a respirasome structure with cytochrome c binding.

This study develops nMITO, engineered mitochondria that target inflammation and repair in acute organ injuries, showing efficacy in mouse models of myocardial, liver, and pancreatitis injuries.

The paper identifies Mix17 as a Mia40 substrate in yeast that spans the mitochondrial outer membrane and exposes its N-terminus to the cytosol, mediated by its interaction with Tom40.

This study shows that EMC complex dysfunction in fission yeast impairs mitochondrial respiration and quiescence, with rescue via membrane fluidity and sterol composition changes.

This study generates hiPSC-derived myofibres with the m.3243A>G mutation to model mitochondrial disease, showing metabolic and physiological changes related to mutation load.