Ion channel regulation and function

The paper uses two Kv2 inhibitors to distinguish Kv2/KvS heteromer conductances from Kv2-only channels in neurons.

This paper uses AlphaFold to predict discrete conformational states of hERG channels, revealing structural features and drug interactions that improve drug safety screening.

This study investigates how different lipid species affect the function of mechanosensitive channels in E. coli, finding that cardiolipin is important for MscS adaptive behavior.

This study identifies a lipid-mediated mechanism by which the mechanosensitive channel MscS inactivates, showing that intercalated lipids physically decouple tension-sensing helices from the gate.

This study uses computational modeling to show that hyperpolarization-activated inward currents (h-currents) can facilitate postinhibitory excitation in human motoneurons.

This paper uses photo-crosslinking to study how the PAS domain of hERG channels affects channel kinetics and voltage dependence, showing state-dependent changes in activation and deactivation.

This study identifies LMAN2 as a regulatory protein that modulates redox-sensitive gating of Kv1.2 channels by altering activation kinetics and redox sensitivity.

This study shows that KCNQ2/3 channels are targeted by mAChR activation in mammalian vestibular afferents, modulating slow excitation and discharge rates.

The paper investigates motifs in CaV2.1 subunits that regulate presynaptic abundance and preference, finding distinct motifs control abundance versus preference.

The paper identifies the C-terminus of voltage-gated Ca2+ channels as the determinant for their compartment-specific targeting in neurons.

This study investigates whether ethanol's interaction with BK channel α subunit residue K361 mediates behavioral responses to alcohol in mice, finding no significant effects on ethanol-related behaviors or consumption.

The paper determines high-resolution structures of Slo1 channels with mutations and LRRC26 subunits to elucidate voltage and auxiliary subunit regulation mechanisms.

This study uses voltage-clamp fluorometry to map conformational changes in the 5-HT3 serotonin-gated channel, linking them to electrophysiological states and agonist effects.

This study uses biophysical models to show how varying Kv2.1 channel expression affects electrophysiological phenotypes through changes in phase plane geometry and bifurcation sequences.

The paper investigates how asymmetric conformational changes in CaV1.3 channels mediate voltage- and calcium-dependent inactivation through distinct molecular mechanisms.

This study identifies CDKL5 as a kinase that phosphorylates Cav2.3, altering its function and contributing to neuronal excitability in CDKL5 deficiency disorder.

The paper introduces an application to visualize mutations on voltage-gated sodium channels using D3.js, enabling customization and high-quality figure creation for genotype/phenotype studies.

This study identifies mitoBKCa, a BKCa splice variant in mitochondria of breast cancer cells, showing it modulates energy production and promotes proliferation, suggesting it as a potential therapeutic target.

This study shows that mutations conferring tetrodotoxin resistance in snake sodium channels impair channel function and muscle performance, revealing functional trade-offs in predator-prey coevolution.

The paper identifies structural elements in OSCA channels that differentially mediate stretch and poking activation through mutagenesis and electrophysiology.

This study investigates the role of CaV3.1 T-type Ca2+ channels in myogenic tone and calcium wave generation in mouse mesenteric arteries, finding reduced tone and calcium waves in their absence.

This study shows that M-type potassium currents influence motoneuron recruitment by modulating subtype-specific firing properties and recruitment gain in mice.

The paper shows that SAK3, a T-type calcium channel enhancer, causes different effects on proliferation and calcium levels in two luminal-A breast cancer cell lines.

The paper develops an optimized protocol for cloning unstable plasmids encoding sodium channel subunits, improving plasmid quality and sequence accuracy.

The paper shows mechanical force activates TREK-1 channels via PLD2 and lipid clustering, leading to second messenger signaling and ion flow.

The paper shows that biophysical properties of Na+ and K+ channels in human pyramidal neurons enable fast and reliable input-output signaling.

This study examines how a KCNT1 gain-of-function variant affects SST and PV GABAergic neurons, revealing differential functional outcomes and potential pathogenic mechanisms in DEEs.

This study investigates how motoneuron size relates to bistability in mouse spinal motoneurons, finding that larger neurons exhibit higher bistability due to specific ionic currents.

This study defines the structural states and curvature-based activation/inactivation mechanisms of PIEZO1 using a mutant and molecular dynamics simulations.

This study shows that aging affects sympathetic motor neurons, increasing their firing responses and reducing M current, contributing to sympathetic overactivity in older mice.