Author

F. Ginty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Assay:imaging· 6 Research Focus:differential expression· 5 Approach:deep learning· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 3 Assay:spatial transcriptomics· 2

Frequent Co-Authors

E. McDonough· 5 shared S. Cho· 4 shared A. Sood· 3 shared M. Salvucci· 3 shared A. Corwin· 2 shared A. Santamaria-Pang· 2 shared D. B. Longley· 2 shared J. H. M. Prehn· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersCancer Biology

E. McDonough

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Spatial Effects of Infiltrating T cells on Neighbouring Cancer Cells and Prognosis in Stage III CRC patients

M. Azimi, S. Cho, E. Bozkurt, E. McDonough, B. Kisakol, A. Matveeva, M. Salvucci, H. Dussmann, C. Firat, N. Urganci, J. Shia, S. McDade, D. B. Longley, F. Ginty, J. H. M. Prehn

The paper investigates the spatial relationship between T cells and cancer cells in stage III CRC patients, finding that closer proximity of T cells to cancer cells is associated with better disease-free survival.

bioRxiv · Jan 30, 2024Cancer Biology

Decoding mTOR signalling heterogeneity in the tumour microenvironment using multiplexed imaging and graph convolutional networks

R. Zuhair, M. Eastwood, M. Jones, A. Cross, J. Hester, F. Issa, F. Ginty, H. Sailem

The paper uses multiplexed imaging and graph convolutional networks to analyze mTOR signaling heterogeneity in colorectal tumors and its correlation with patient prognosis.

bioRxiv · Dec 30, 2023 · PreprintCancer Biology

Neutrophils reprograms the bone marrow to impair T-cell immunity during tuberculosis

M. Saqib, E. McDonough, S. Das, Z. Cheng, P. Sankar, F. Li, Q. Yang, Y. Xu, W. Wang, X. Chen, A. K. Ojha, F. Ginty, Y. Cai, B. B. Mishra

This study shows that neutrophils in tuberculosis promote pathologic hematopoiesis by producing G-CSF, which impairs T-cell immunity through IFNAR1 signaling.

bioRxiv · Jun 28, 2022 · PreprintImmunology

Human Digital Twin: Automated Cell Type Distance Computation and 3D Atlas Construction in Multiplexed Skin Biopsies

S. Ghose, Y. Ju, E. McDonough, J. Ho, A. Karunamurthy, C. Chadwick, S. Cho, R. Rose, A. Corwin, C. Surrette, J. S. Martinez, E. Williams, A. Sood, Y. Al-Kofahi, L. D. Falo, , F. Ginty

The paper develops a 3D workflow to analyze multiplexed skin biopsy data, revealing age-related changes in DNA repair and immune cell ratios.

bioRxiv · Mar 30, 2022Cell Biology

Anatomical Structures, Cell Types, and Biomarkers Tables Plus 3D Reference Organs in Support of a Human Reference Atlas

K. Borner, S. A. Teichmann, E. M. Quardokus, J. Gee, K. Browne, D. Osumi-Sutherland, B. W. Herr, A. Bueckle, H. Paul, M. A. Haniffa, L. Jardine, A. Bernard, S.-L. Ding, J. A. Miller, S. Lin, , G. Weber

The paper reviews efforts to create human anatomical structures, cell types, and biomarkers tables and 3D reference organs to support a Human Reference Atlas, with use cases showing their utility in biomedical research.

bioRxiv · May 31, 2021Cell Biology

An atlas of inter- and intra-tumor heterogeneityof apoptosis competency in colorectal cancertissue at single cell resolution

A. U. Lindner, M. Salvucci, E. MCDonough, S. Cho, X. Stachtea, E. P. O'Connell, A. D. Corwin, A. Santamaria-Pang, S. Carberry, M. Fichtner, S. Van Schaeybroeck, P. Laurent-Puig, J. P. Burke, D. McNamara, M. Lawler, , J. H. Prehn

The paper generates an atlas of apoptosis susceptibility heterogeneity in colorectal cancer using single-cell analysis and ODE modeling, identifying intrinsic cellular differences in apoptosis competency.

bioRxiv · Mar 19, 2021Cancer Biology

Stratification Of Chemotherapy-Treated Stage III Colorectal Cancer Patients Using Multiplexed Imaging And Single Cell Analysis Of T Cell Populations

X. Stachtea, M. B. Loughrey, M. Salvucci, A. Lindner, S. Cho, E. McDonough, A. Sood, J. Graf, A. Santamaria-Pang, A. Corwin, P. Laurent-Puig, S. Dasgupta, S. Van Schaeybroeck, M. Lawler, J. H. M. Prehn, , D. B. Longley

This study uses multiplexed imaging and single-cell analysis to classify immune cells in stage III colorectal cancer patients, finding that multi-marker Treg classification better predicts survival than single markers.

bioRxiv · Feb 24, 2021Cancer Biology

Spatial domain analysis predicts risk of colorectal cancer recurrence and infers associated tumor microenvironment networks

S. Uttam, A. M. Stern, S. Furman, F. Pullara, D. Spagnolo, L. Nguyen, A. H. Gough, C. Sevinsky, F. Ginty, D. L. Taylor, S. C. Chennubhotla

The paper develops a spatial analytics platform to predict colorectal cancer recurrence and infer tumor microenvironment networks from spatial data.

bioRxiv · Dec 11, 2019Cancer Biology