M. E. Ritchie

Early cytokine-driven adaptation of survival pathways in lymphoid cells during targeted therapies

This study shows that CLL cells rapidly adapt to venetoclax by upregulating pro-survival proteins and cytokines, suggesting combination therapies targeting these pathways could improve treatment outcomes.

Metabolic scaling in small life forms

This study presents a new model explaining metabolic scaling in small life forms, showing how metabolic rates scale with cell size and predicting a transition point between prokaryotes and eukaryotes.

An immunohistochemical atlas of necroptotic pathway expression

The paper develops automated immunohistochemistry protocols to detect necroptotic pathway proteins in mouse and human tissues, revealing heterogeneity and disease-related changes in expression.

Metabolism regulates muscle stem cell self-renewal by connecting the microenvironment and histone acetylation

The paper identifies how extracellular monosaccharide availability influences muscle stem cell self-renewal through histone acetylation and metabolic signaling.

Establishment of cell transcriptional identity during seed germination

This study maps the temporal changes in cell-type specific gene expression during Arabidopsis seed germination, revealing a shared initial transcriptional state followed by distinct regulatory programs.

Integrating defense and leaf economic spectrum traits in a tropical savanna plant

This study examines correlations between defense traits and leaf economic spectrum traits in Solanum incanum, finding structural defenses align with resource conservative traits while chemical defenses align with resource acquisitive traits.

Actinobacillus pleuropneumoniae encodes multiple phase-variable DNA methyltransferases that comprise distinct phasevarions

This study identifies multiple phase-variable DNA methyltransferases in Actinobacillus pleuropneumoniae, showing their role in regulating phasevarions and pathogenic traits.

Landscape variation in defense traits along gradients of multiple resources and mammalian herbivory

The paper examines how defense traits in plants vary along gradients of resources and herbivory, finding that spine density is influenced by both resource availability and herbivory intensity.

A method for stabilising the XX karyotype in female mESC cultures

This paper describes a method to maintain XX karyotype in female mESCs, preventing their transition to XO and preserving female-specific pluripotency.

Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate

The paper investigates how arginine-rich DPRs from C9ORF72 expansions stall ribosomes and shows that this stalling differs from canonical RQC substrates, with no natural regulatory responses.

Large herbivore impact on plant biomass along multiple resource gradients in the Serengeti

The paper tests hypotheses about herbivore impact on plant biomass along resource gradients in the Serengeti, finding that herbivore effects are driven by plant phosphorus content rather than nitrogen or rainfall.

A burning question: Can savannah fire management generate enough carbon revenue to help save the lion from extinction?

This paper estimates carbon revenue from savanna fire management to fund lion conservation in Africa, finding potential revenues of $59.6-$1.7B/year at $5-$13/ton.

The clonal and molecular aetiology of emergency dendritic cell development

This study investigates Flt3L-driven emergency dendritic cell development, revealing clonal expansion and molecular mechanisms in HSPCs leading to cDC1 generation.

Xmas ESC: A new female embryonic stem cell system that reveals the BAF complex as a key regulator of the establishment of X chromosome inactivation

The paper introduces a female ESC system called Xmas that identifies the BAF complex as essential for X chromosome inactivation.

Vasoactive intestinal peptide confers anticipatory mucosal immunity by regulating ILC3 activity

This study shows that vasoactive intestinal peptide (VIP) regulates ILC3 activity to enhance IL-22 production and confer gut protection through the VIP-VIPR2 pathway.