A. Huttenlocher

This study shows that human neutrophils shift nutrient preference from glycogen to glucose upon activation, with function-specific metabolic dependencies.

This study investigates the dual role of naive primary neutrophils in the tumor microenvironment, showing they both restrict tumor invasion and hinder NK cell penetration through ROS and NETs.

This paper introduces a liquid-liquid interface system to model in vivo neutrophil migration, finding that neutrophils use bleb-based force generation to deform barriers under confining pressures.

This study shows that deleting PTP1B phosphatase enhances iPSC-derived neutrophil motility, antimicrobial function, and response to fungal pathogens.

The paper shows thermal injury causes keratinocyte migration and ROS production, which affects sensory axon regeneration, while mechanical injury does not.

This paper introduces a light sheet FLIM system using SPAD arrays for fast, label-free single-cell NAD(P)H autofluorescence imaging in live cells and organisms.

This paper identifies a novel lymphoid network in zebrafish that enables whole-body T cell surveillance without lymph nodes, supporting both collective migration and antigen search.

This paper uses in vivo FLIM to track metabolic changes in macrophages during wound responses in zebrafish, showing dynamic shifts in NAD(P)H and FAD redox ratios.

This study characterizes two clinical isolates of A. nidulans, showing differences in growth, metabolism, stress response, and virulence compared to a reference strain.

This study shows that Padi2-mediated citrullination is essential for wound response and tissue regeneration in zebrafish by promoting histone modification and cell proliferation in the notochord bead.

This study identifies C3A's role in neutrophil migration to tissue damage using TRAP-seq in zebrafish and shows impaired responses in c3a.1-/- larvae.

This study shows that DNAJB1-PRKACA fusion induces liver inflammation in a zebrafish FLC model by increasing immune cell infiltration and promoting a pro-inflammatory microenvironment.

The paper uses zebrafish to study how neutrophil ROS affects fungal growth and inflammation during infection with Aspergillus nidulans, finding that ROS limits fungal growth and reduces inflammation in PHOX-deficient hosts.

The paper identifies miR-199 as a suppressor of neutrophil migration and inflammation by targeting CDK2, revealing a noncanonical role for CDK2 in cell polarity and chemotaxis.