A. Combes

Identification of a conserved subset of cold tumors responsive to immune checkpoint blockade

This study identifies a biomarker, {beta}Alt, that predicts immune checkpoint blockade response in cold tumors by integrating TGF{beta} signaling, DNA repair, and immune context signatures.

Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors

The paper identifies a potent effector state among exhausted CD8 T cells in tumors using multimodal CITE-Seq, showing enhanced cytokine production and tumor-killing ability.

Tumor cell heterogeneity drives spatial organization of the intratumoral immune response in squamous cell skin carcinoma

This study shows that tumor cell heterogeneity influences the spatial organization of immune responses in squamous cell skin carcinoma, affecting immunotherapy outcomes.

Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis

This study uses single-cell and spatial multi-omics to show VDZ affects mononuclear phagocyte subsets and highlights gene expression patterns in UC.

Myeloid mechano-metabolic programming restricts anti-tumor immunity

This study shows that fibrotic tumor microenvironments impair anti-tumor immunity through myeloid cell-driven metabolic changes that hinder CD8+ T cell function.

Persistence of microcystin production of Planktothrix agardhii exposed to different salinity concentrations.

This study investigates microcystin production in Planktothrix agardhii under varying salinity levels, finding that the species maintains toxin production even at higher salinities.

Specific metabolic signatures of fish exposed to cyanobacterial blooms

The paper analyzes liver metabolomes of two fish species exposed to cyanobacterial blooms and finds similar metabolic changes across species.