Author

A. Leach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:metabolomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:diffusion model· 1

Frequent Co-Authors

A. B. Aurora· 2 shared D. Bezwada· 2 shared R. J. DeBerardinis· 2 shared A. Bagrodia· 1 shared A. Liesz· 1 shared A. M. Poole· 1 shared A. Tasdogan· 1 shared A. Tovchigrechko· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

A. B. Aurora

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

FrameDiPT: SE(3) Diffusion Model for Protein Structure Inpainting

C. Zhang, A. Leach, T. Makkink, M. Arbesu, I. Kadri, D. Luo, L. Mizrahi, S. Krichen, M. Lang, A. Tovchigrechko, N. Lopez Carranza, U. Sahin, K. Beguir, M. Rooney, Y. Fu

FrameDiPT is a diffusion model for protein structure inpainting that recovers masked sections using sequence and structural context, achieving comparable accuracy to existing models with limited data.

bioRxiv · Nov 21, 2023 · PreprintImmunology

Mitochondrial metabolism in primary and metastatic human kidney cancers

D. Bezwada, R. J. DeBerardinis, N. P. Lesner, B. Brooks, H. S. Vu, Z. Wu, L. Cai, S. Kasitinon, S. Kelekar, F. Cai, A. B. Aurora, M. Patrick, A. Leach, R. Ghandour, Y. Zhang, , V. Margulis

This study investigates mitochondrial metabolism in kidney cancers, finding that primary tumors have suppressed mitochondrial function while metastases show enhanced TCA cycle labeling.

bioRxiv · Feb 6, 2023Cancer Biology

Discovery of an AIM2 inflammasome inhibitor for the treatment of DNA-driven inflammatory disease.

J. P. Green, L. Y. El-Sharkawy, S. Roth, J. Zhu, J. Cao, A. Leach, A. Liesz, S. Freeman, D. Brough

The paper identifies inhibitors of DNA sensors like AIM2, cGAS, and TLR9, including 4-sulfonic calixarenes and suramin, showing potential for treating DNA-driven inflammatory diseases.

bioRxiv · Jul 28, 2022Immunology

G6PD deficiency sensitizes metastasizing melanoma cells to oxidative stress and glutaminolysis

A. B. Aurora, V. Khivansara, A. Leach, J. G. Gill, M. Martin-Sandoval, C. Yang, S. Y. Kastininon, D. Bezwada, A. Tasdogan, W. Gu, T. P. Mathews, Z. Zhao, R. J. DeBerardinis, S. J. Morrison

This study shows that G6PD deficiency in melanoma cells increases oxidative stress and glutaminolysis, reducing metastasis by making cells more vulnerable to metabolic disruption.

bioRxiv · Nov 11, 2021 · PreprintCancer Biology