A. Srivastava

This study combines two nanoparticle approaches to induce antigen-specific tolerance in mice, showing synergy in delaying autoimmune arthritis.

This study investigates how antibody 3D11 binds to Plasmodium berghei CSP repeats, inducing structural ordering and revealing common mechanisms of antibody evolution against Plasmodium CSP.

The paper reports the production of a multi-antigenic SARS CoV-2 virus-like particle (VLP) in Saccharomyces cerevisiae as a vaccine candidate, confirmed by TEM and analytical data.

This study uses molecular dynamics simulations to show that multiple gp41 trimers and host cell lipidomes are required for efficient HIV-1 membrane fusion.

This paper uses SVM to analyze molecular simulations of lipid bilayers, showing how interface detection and fluctuation spectra depend on resolution and geometry.

This study identifies sequence-dependent DNA-DNA condensation mediated by divalent cations, revealing a mechanism involving sequence-enhanced major groove binding.

This study shows that hepatocyte-derived microRNA, particularly miR-122, is transferred to kidney tubular cells and regulates CYP2E1 expression, influencing drug toxicity.

This study shows that copy number profiles are conserved in patient-derived xenografts (PDXs) through engraftment and passaging, indicating minimal impact from the mouse host on tumor evolution.

The paper investigates the joint contribution of genetics and DNA methylation to phenotypic variation in Brachypodium under simulated natural conditions, finding limited but significant epigenomic influence.

The paper tests the reproducibility of PDX drug responses and sequence results across different labs using standardized protocols and workflows.

This study describes a method to purify native CCL7 and its isotopically labeled derivatives, enabling structural and functional studies of chemokine receptor interactions.

This study uses scRNA-seq to analyze cellular heterogeneity and stress adaptation in Plasmodium falciparum under temperature stress, identifying gametogenesis primed cells and stress response mechanisms.

The paper identifies a dynamic loop in cryptochromes that regulates their differential binding to CLOCK:BMAL1, explaining their distinct roles in circadian rhythms.

The paper identifies structural differences between β-arrestin isoforms using conformational sensors and domain-swapping, linking these differences to their distinct functional outcomes in GPCR signaling.

The paper identifies SCREAM as a scaffold that recruits MPK3/6 to downregulate SPEECHLESS, enforcing stomatal initiation through a bipartite motif interaction.

This study investigates the energy landscape of lipid bilayers, finding that in-vivo systems exhibit frustrated landscapes enabling diverse nanoscale patterns compared to in-vitro systems.

The paper shows mechanical stress, specifically shear stress, disrupts the CusCBA efflux complex in E. coli, increasing metal toxicity susceptibility.

This study investigates ligand bias at C5aR1 by comparing C5a and C5apep, showing differential activation of G proteins, βarr recruitment, endocytosis, and ERK1/2 phosphorylation.

This study investigates NGF expression in breast phyllodes tumours and finds higher NGF levels compared to fibroadenomas, suggesting its potential as a biomarker.

This study characterizes liquid-liquid phase coexistence in biomembranes using non-affine deformation and topological rearrangements, identifying ordered and disordered phases without prior lipid knowledge.

This study investigates how HIV-1 Gag polyprotein assembly is regulated by RNA and the plasma membrane using computational and experimental methods, revealing scaffolding roles for these components.