B. Taylor

AHR activation accelerates the resolution of TGF-β1 induced fibroblast activation and promotes alveolar type 1 cell regeneration in alveolar organoids

The paper identifies DB-11-BE87 as a compound that promotes AT1 cell regeneration by reducing TGF-β1-induced fibroblast activation through AHR activation in alveolar organoids.

Glioblastoma Mesenchymal Transition and Invasion are Dependent on a NF-κB/BRD2 Chromatin Complex

This study identifies the PTEN-NF-κB-BRD2 pathway as critical for glioblastoma mesenchymal transition and invasion, suggesting BET-BD2 inhibitors as a therapeutic strategy.

Physiological adaptation to high irradiance in duckweeds depends on light habitat niche and is ecotype and species-specific.

The paper examines how duckweed ecotypes and species adapt to high light conditions, finding species-specific physiological responses and ecotype-specific acclimation abilities.

yEvo: a modular eukaryotic genetics and evolution research experience for high school students

yEvo provides high school students with modular yeast evolution experiments to explore mutation, adaptation, and evolution through hands-on research.

Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity

This study shows that commensal bacteria modify heparan sulfate, reducing SARS-CoV-2 spike protein binding and that this bacterial presence decreases with age, increasing COVID-19 susceptibility.

Dynamic multi-OMICs of glioblastoma reveal sensitivity to neddylation inhibition dependent on nuclear PTEN and DNA replication pathways

The paper investigates the dynamic multi-OMICs of glioblastoma and identifies sensitivity to neddylation inhibition, though the manuscript was withdrawn due to un reproducible findings.

Identification and physiological significance of temporal NFκB signaling codewords deployed by macrophages to classify immune threats

This study identifies six temporal NFκB signaling codewords used by macrophages to classify immune threats and shows their role in inflammatory pathology.

Molecular competition in G1 controls when cells simultaneously commit to terminally differentiate and exit the cell-cycle

The paper shows that in G1 phase, a molecular competition between cyclin D1 and p21 regulates simultaneous commitment to differentiation and cell cycle exit in adipogenesis.

Identification of a small molecule that stimulates human beta-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells

Loss of adipocyte identity through synergistic repression of PPARγ by TGF-β and mechanical stress

The paper shows that TGF-β and mechanical stress together repress PPARγ, causing adipocytes to lose identity and convert into myofibroblasts in a fibrosis model.