N. Tang

A cocktail containing two synergetic antibodies broadly neutralizes SARS-CoV-2 and its variants including Omicron BA.1 and BA.2

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine booster

This study shows that an Omicron-specific subunit vaccine booster enhances neutralizing antibodies against SARS-CoV-2 variants and the ancestral virus, with a two-dose WT-RBD plus Omicron-RBD booster showing the strongest response.

Reduced infectivity but increased immune escape of the new SARS-CoV-2 variant of concern Omicron

This study assesses the infectivity and immune evasion of the Omicron SARS-CoV-2 variant using pseudotyped viruses and neutralizing assays against convalescent sera and vaccinated individuals.

Reduced neutralization of SARS-CoV-2 B.1.617 variant by inactivated and RBD-subunit vaccine

The paper evaluates the neutralization efficacy of inactivated and RBD-subunit vaccines against SARS-CoV-2 B.1.617 and B.1.1.7 variants using a pseudovirus-based assay.

Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

Decoding regulatory specificity of human ribosomal proteins

This study shows that ribosomal protein (RP) deficiency affects gene expression through translational and transcriptional changes, with distinct impacts on cell growth, apoptosis, and development.

Bacterial-type plant ferroxidases tune local phosphate sensing in root development

The paper shows that bacterial-type ferroxidases in Arabidopsis thaliana modulate phosphate sensing in roots by regulating iron homeostasis and growth under phosphate limitation.

Emerging SARS-CoV-2 variants reduce neutralization sensitivity to convalescent sera and monoclonal antibodies

This study evaluates the neutralization sensitivity of SARS-CoV-2 variants N501Y.V1 and N501Y.V2 to convalescent sera and monoclonal antibodies, finding reduced neutralization activity.

GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis

This study shows GSTZ1 enhances sorafenib-induced ferroptosis in HCC by inhibiting the NRF2/GPX4 axis, and its deficiency leads to resistance to sorafenib.

Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products in vitro

This study identifies bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors through in vitro screening of natural products.

VPS13D bridges the ER to Miro containing membranes

The paper shows VPS13D bridges ER and Miro-containing membranes to facilitate lipid transport between ER and mitochondria, linking yeast and metazoan functions of Gem1/Miro.

A key linear epitope for a potent neutralizing antibody to SARS-CoV-2 S-RBD

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

A rapid and efficient screening system for neutralizing antibodies and its application for the discovery of potent neutralizing antibodies to SARS-CoV-2 S-RBD

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

Gluconeogenic Enzyme PCK1 Deficiency Is Critical for CHK2 O-GlcNAcylation and Hepatocellular Carcinoma Growth upon Glucose Deprivation

This study shows that PCK1 deficiency increases O-GlcNAcylation and promotes HCC growth under glucose deprivation by enhancing CHK2 activity.

Dynamic multi-OMICs of glioblastoma reveal sensitivity to neddylation inhibition dependent on nuclear PTEN and DNA replication pathways

The paper investigates the dynamic multi-OMICs of glioblastoma and identifies sensitivity to neddylation inhibition, though the manuscript was withdrawn due to un reproducible findings.

The D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity

This study shows the D614G mutation in SARS-CoV-2 spike protein increases viral infectivity and is more susceptible to elastase cleavage, with minimal impact on neutralizing antibody efficacy.

Transgenerational inheritance of abnormal spermatogenesis with Igf2/H19 epigenetic alteration in CD1 mouse induced by in utero arsenic exposure

This study shows that prenatal arsenic exposure in mice leads to transgenerational impairments in spermatogenesis, associated with epigenetic changes in Igf2 and H19.

O-GlcNAcylation of SAMHD1 Indicating a Link between Metabolic Reprogramming and Anti-HBV Immunity

This study shows that HBV infection enhances the hexosamine biosynthesis pathway, leading to O-GlcNAcylation of SAMHD1, which boosts antiviral immunity against HBV and HIV-1.

Benchmarking Computational Methods for Estimating the Pathogenicity of Wilson’s Disease Mutations

This study benchmarks 16 computational methods for predicting pathogenicity of ATP7B mutations in Wilson's disease, finding wide variation in method quality and highlighting threshold optimization issues.

Membrane dynamics of Notch-bound γ-secretase produces two distinct Notch conformations

The paper uses molecular dynamics simulations to study Notch cleavage by γ-secretase in a membrane environment, identifying conformational states that explain imprecise cleavage and potential drug targets.

Ponatinib shows potent antitumor activity in small cell carcinoma of the ovary hypercalcemic type (SCCOHT) through multi-kinase inhibition

This paper identifies ponatinib as a potent treatment for SCCOHT by inhibiting multiple kinases in preclinical models.