C. Werner

A precision microgel platform to direct vascular morphogenesis in vitro

This paper introduces a microgel platform that precisely controls morphogen gradients to guide vascular morphogenesis in vitro.

Dynamic matrices with DNA-encoded viscoelasticity for advanced cell and organoid culture

This paper introduces DyNAtrix, a DNA-encoded hydrogel that allows precise control over viscoelastic properties for 3D cell and organoid cultures.

Leaf-level metabolic changes in response to drought affect daytime CO2 emission and isoprenoid synthesis pathways

This study examines how drought affects CO2 emission and isoprenoid synthesis in tropical tree leaves, finding that drought-sensitive species show greater reductions in daytime CO2 production and altered VOC allocation.

Skin epithelial cells change their mechanics and proliferation upon Snail-mediated EMT signalling

This study shows that Snail-mediated EMT in skin epithelial cells alters cellular mechanics, mitotic rounding, and proliferation, with implications for skin tumor progression.

Mapping tumor spheroid mechanics in dependence of 3D microenvironment stiffness and degradability by Brillouin microscopy

This study uses Brillouin microscopy to map tumor spheroid mechanics in 3D hydrogels, showing that stiffness and degradability affect mechanical properties and cell invasion.

Explicit expression of mesophyll conductance in the traditional leaf photosynthesis-transpiration coupled model and its physiological significances

This study develops a photosynthesis-transpiration coupled model that explicitly incorporates mesophyll conductance, improving predictions of leaf gas exchange by optimizing parameterization methods.

Autoantibodies against Progranulin and IL-1 receptor antagonist due to immunogenic posttranslational isoforms contribute to hyperinflammation in critically ill COVID-19

This study identifies autoantibodies against PGRN and IL-1-Ra in critical COVID-19 patients, linked to hyperphosphorylated isoforms and increased inflammation.

EMT-induced cell mechanical changes enhance mitotic rounding strength

This study shows that EMT in breast epithelial cells enhances mitotic rounding strength through changes in Rho GTPase activity, aiding cancer cells in mitosis under mechanical stress.

3D microenvironment stiffness regulates tumor spheroid growth and mechanics via p21 and ROCK

This study shows that 3D microenvironment stiffness affects tumor spheroid growth and mechanics through p21 and ROCK pathways.

Polyacrylamide Bead Sensors for in vivo Quantification of Cell-Scale Stress in Zebrafish Development

The paper develops PAAm bead sensors to measure cell-scale stress in zebrafish embryos and uses COMPAX to detect stress patterns during development.

Standardized microgel beads as elastic cell mechanical probes

This paper presents standardized poly-acylamide microgel beads as mechanical probes for cell mechanics, showing they can be calibrated to mimic cell elasticity and used for cross-comparison of measurement techniques.

Evolutionary proteomics uncovers ciliary signaling components

The paper uses proteomic analysis of cilia from diverse organisms to identify conserved ciliary proteins and their ancient signaling connections, revealing a novel protein involved in vertebrate development and human disease.