R. Lafyatis

Genetic regulation and targeted reversal of lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension

The paper identifies NCOA7's role in lysosomal function and inflammatory sterol metabolism in PAH, showing its deficiency exacerbates disease through oxysterol/bile acid generation.

An individualized causal framework for learning intercellular communicationnetworks that define microenvironments of individual tumors

The paper develops a causal framework to identify tumor-specific intercellular communication networks in head and neck squamous cell carcinoma, revealing subtype-specific patterns linked to clinical outcomes.

Myofibroblast transcriptome indicates SFRP2+ fibroblast progenitors in systemic sclerosis skin

The paper identifies SFRP2+ fibroblast progenitors as the source of myofibroblasts in systemic sclerosis skin using single-cell RNA sequencing.

Adipocyte lipolysis abrogates skin fibrosis in a Wnt/DPP4-dependent manner

This study shows that adipocyte lipolysis, regulated by Wnt signaling and DPP4, reduces skin fibrosis by modulating ECM homeostasis.

Divergent cancer etiologies drive distinct B cell signatures and tertiary lymphoid structures

This study identifies distinct B cell signatures and tertiary lymphoid structures in HPV+ and HPV- HNSCC, highlighting their role in antitumor immunity.