Author

D. J. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 3 Cell Biology· 2 Animal Behavior & Cognition· 1 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 9 Approach:experimental assay· 8 Organism:human· 5 Organism:mouse· 5 Assay:proteomics· 4 Approach:statistical model· 4 Assay:imaging· 2 Assay:behavioral assay· 1

Frequent Co-Authors

S. H. Wilks· 4 shared A. Netzl· 3 shared B. Mühlemann· 3 shared F. Krammer· 3 shared C. Drosten· 2 shared D. C. Montefiori· 2 shared J. C. Kirkman-Brown· 2 shared L. M. Jeworowski· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersImmunology

S. H. Wilks

Mutual co-authors in cluster

Author profile →

13 papers

Recent·Most cited

Global variation in prior exposure shapes antibody neutralization profiles of SARS-CoV-2 variants up to BA.2.86

S. Turner, G. Amirthalingam, D. Bailey, D. H. Barouch, K. R. Bewley, K. Brown, Y. R. Cao, Y.-W. Chan, S. Charlton, DOVE consortium, N. S. Coombes, B. Hallis, D. D. Ho, F. Jian, N. Lasrado, , D. J. Smith

The paper analyzes antibody neutralization data from multiple countries to assess how prior exposure to SARS-CoV-2 variants affects neutralization profiles of BA.2.86 and its descendants.

bioRxiv · Mar 27, 2024 · PreprintImmunology

Direct comparison of SARS-CoV-2 variant specific neutralizing antibodies in human and hamster sera

A. Roessler, A. Netzl, L. Knabl, S. H. Wilks, B. Muehlemann, S. Tuereli, A. Mykytyn, D. von Laer, B. L. Haagmans, D. J. Smith, J. Kimpel

This study compares neutralizing antibody titers in human and hamster sera against SARS-CoV-2 variants using a live-virus neutralization assay, finding hamster sera show higher reactivity.

bioRxiv · Dec 19, 2023Immunology

Antigenic cartography using variant-specific hamster sera reveals substantial antigenic variation among Omicron subvariants

B. Mühlemann, J. Trimpert, F. Walper, M. L. Schmidt, S. Schroeder, L. M. Jeworowski, J. Beheim-Schwarzbach, T. Bleicker, D. Niemeyer, J. M. Adler, R. M. Vidal, C. Langner, D. Vladimirova, D. J. Smith, M. Voss, , C. Drosten

The paper uses hamster sera from variant-specific infections to map antigenic differences among SARS-CoV-2 variants, revealing significant antigenic variation among Omicron subvariants.

bioRxiv · Jul 2, 2023Immunology

Axonemal regulation by curvature explains sperm flagellar waveform modulation

M. T. Gallagher, J. C. Kirkman-Brown, D. J. Smith

This paper introduces a biomechanical model to explain how sperm flagellar waveform changes in response to environmental and physiological factors.

bioRxiv · Jul 20, 2022Cell Biology

Omicron BA.1 and BA.2 are antigenically distinct SARS-CoV-2 variants

A. Z. Mykytyn, M. Rissmann, A. Kok, M. Rosu, D. Schipper, T. I. Breugem, P. B. van den Doel, F. Chandler, T. Bestebroer, M. de Wit, M. E. van Royen, R. Molenkamp, B. Oude Munnink, R. D. de Vries, C. GeurtsvanKessel, , B. Haagmans

This study compares the antigenic differences between SARS-CoV-2 Omicron BA.1 and BA.2 variants using antigenic cartography and hamster sera, finding they are distinct antigenic outliers.

bioRxiv · Feb 23, 2022 · PreprintMicrobiology

Mapping SARS-CoV-2 antigenic relationships and serological responses

S. H. Wilks, B. Muhlemann, X. Shen, S. Tureli, E. B. LeGresley, A. Netzl, M. A. Caniza, J. N. Chacaltana-Huarcaya, V. M. Corman, X. Daniell, M. B. Datto, F. S. Dawood, T. N. Denny, C. Drosten, R. A. M. Fouchier, , D. J. Smith

The paper uses antigenic cartography to analyze cross-reactivity among SARS-CoV-2 variants and human sera, identifying amino acid substitutions and immunodominance patterns affecting immune escape and vaccine efficacy.

bioRxiv · Jan 28, 2022Immunology

Combining antigenic data from public sources gives an early indication of the immune escape of emerging virus variants

A. Netzl, S. Tureli, E. LeGresley, B. Mühlemann, S. H. Wilks, D. J. Smith

The paper aggregates and analyzes antigenic data from multiple sources to assess immune escape of the Omicron BA.1 variant and shows reliable results after one month of data collection.

bioRxiv · Dec 31, 2021 · PreprintImmunology

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains

B. Ying, B. Whitener, L. A. VanBlargan, A. O. Hassan, S. Shrihari, C.-Y. Liang, C. E. Karl, S. Mackin, R. E. Chen, N. M. Kafai, S. H. Wilks, D. J. Smith, J. M. Carreno, G. Singh, F. Krammer, , M. S. Diamond

This study evaluates the protective efficacy of mRNA vaccines against SARS-CoV-2 variants in mice, showing that low-dose vaccines lead to breakthrough infections with Delta variant.

bioRxiv · Aug 25, 2021Microbiology

Vaccination with B.1.1.7, B.1.351 and P.1 variants protects mice from challenge with wild type SARS-CoV-2

F. Amanat, S. Strohmeier, P. Meade, N. Dambrauskas, B. Mühlemann, D. J. Smith, V. Vigdorovich, D. N. Sather, L. Coughlan, F. Krammer

This study evaluates cross-neutralizing antibody responses and protective efficacy of vaccines based on SARS-CoV-2 variants B.1.1.7, B.1.351, and P.1 in mice against wild type SARS-CoV-2 challenge.

bioRxiv · Aug 5, 2021 · PreprintImmunology

Extreme Phenotypic Diversity in Operant Responding for an Intravenous Cocaine or Saline Infusion in the Hybrid Mouse Diversity Panel

J. R. Bagley, A. H. Khan, D. J. Smith, J. D. Jentsch

The paper investigates genetic influences on cocaine IVSA in the HMDP, finding substantial heritability and unique genetic variants for cocaine versus saline responding.

bioRxiv · Feb 3, 2021 · PreprintAnimal Behavior & Cognition

Visual Biochemistry: modular microfluidics enables kinetic insight from time-resolved cryo-EM

M.-E. Maeots, B. Lee, A. Nans, S.-G. Jeong, M. M. N. Esfahani, D. J. Smith, C.-S. Lee, S. S. Lee, M. Peter, R. I. Enchev

This paper introduces a time-resolved cryo-EM method using modular microfluidics to visualize biochemical reactions at near-atomic resolution and millisecond timescales, demonstrating its application to RecA filament formation.

bioRxiv · Mar 4, 2020Biochemistry

Rapid sperm capture: High-throughput flagellar waveform analysis

M. T. Gallagher, G. Cupples, E. H. Ooi, J. C. Kirkman-Brown, D. J. Smith

This paper introduces a fully-automated method for analyzing flagellar movement in sperm, revealing that CASA measures beat cross frequency instead of beat frequency and validating track centroid speed as a better indicator of progressive motility.

bioRxiv · Feb 15, 2019Cell Biology

Epistatic interactions can moderate the antigenic effect of substitutions in hemagglutinin of influenza H3N2 virus

B. F. Koel, D. F. Burke, S. van der Vliet, T. M. Bestebroer, G. F. Rimmelzwaan, A. D. M. E. Osterhaus, D. J. Smith, R. A. M. Fouchier

The paper tests how epistatic interactions affect antigenic changes in influenza H3N2 hemagglutinin substitutions at positions 145 and 155.

bioRxiv · Dec 26, 2018Microbiology