L. Fong

PVRL2 Suppresses Anti-tumor Immunity Through PVRIG- and TIGIT-Independent Pathways

This study shows PVRL2 suppresses anti-tumor immunity independently of PVRIG and TIGIT, with deletion reducing tumor growth more than PD-L1 loss.

Tumor cell heterogeneity drives spatial organization of the intratumoral immune response in squamous cell skin carcinoma

This study shows that tumor cell heterogeneity influences the spatial organization of immune responses in squamous cell skin carcinoma, affecting immunotherapy outcomes.

Analysis of evolutionary dynamics and clonal architecture in prostate cancer

This study analyzes prostate cancer clonal architecture and evolutionary dynamics in 845 tumors, finding that Black patients have more monoclonal tumors but higher recurrence rates, and identifies new mutational signatures linked to subclones.

Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted by metastasis

The paper examines CD8+ T cell responses in human lymph nodes during cancer immunotherapy and finds that metastasis disrupts these responses.

Sex Chromosome Heteromorphism and the Fast-X Effect in Poeciliids

This study investigates Fast-X evolution in Poeciliid fish by analyzing sequence divergence and polymorphism across species with varying sex chromosome heteromorphism.

Deep immune profiling reveals targetable mechanisms of immune evasion in checkpoint blockade-refractory glioblastoma

This study identifies immune evasion mechanisms in checkpoint blockade-refractory glioblastoma using deep immune profiling and shows that enhancing antigen presentation can improve immunotherapy response.

TCR convergence in individuals treated with immune checkpoint inhibition for cancer

The paper compares TCR convergence detected by two sequencing platforms in cancer patients and finds Illumina-based sequencing shows higher convergence, which can be used to predict treatment response.