UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins
S. Ninagawa, M. Matsuo, D. Ying, S. Oshita, S. Aso, K. Matsushita, M. Taniguchi, A. Fueki, M. Yamashiro, K. Sugasawa, S. Saito, K. Imami, Y. Kizuka, T. Sakuma, T. Yamamoto, , K. Mori
This study shows UGGT1 reglucosylation competes with EDEM-mediated degradation of misfolded glycoproteins, influencing ER protein quality control.
bioRxiv · Oct 18, 2023Cell Biology