Author

N. Xia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Microbiology· 7 Pathology· 2 Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 17 Research Focus:host-pathogen & immune response· 10 Research Focus:drug response / drug discovery· 7 Organism:human· 6 Organism:mouse· 5 Assay:proteomics· 5 Organism:rat· 4 Organism:non-human primate· 3

Frequent Co-Authors

J. Zhang· 11 shared H. Xiong· 7 shared Q. Yuan· 7 shared T. Zhang· 7 shared Y. Zhang· 7 shared H. Zhu· 6 shared J. Ma· 6 shared J. Xu· 6 shared

Activity by Year

2020-2022 · peak 8/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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11 shared papersMicrobiology

J. Zhang

Mutual co-authors in cluster

Author profile →

18 papers

Recent·Most cited

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

Y. Wu, S. Wang, Y. Zhang, L. Yuan, Q. Zheng, M. Wei, Y. Shi, Z. Wang, J. Ma, K. Wang, M. Nie, J. Xiao, Z. Huang, P. Chen, H. Guo, , N. Xia

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

Cell Host & Microbe · Dec 1, 2022Peer-reviewedMicrobiology

Intranasal delivery of NS1-deleted influenza virus vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response

L. Zhang, Y. Jiang, J. He, J. Chen, R. Qi, L. Yuan, T. Shao, C. Chen, Y. Chen, X. Wang, X. Lei, Q. Gao, C. Zhuang, M. Zhou, J. Ma, , N. Xia

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

bioRxiv · Oct 3, 2022 · PreprintImmunology

PF-D-Trimer, a broadly protective SARS-CoV-2 subunit vaccine: immunogenicity and application

Z. Zhang, J. Zhou, P. Ni, B. Hu, S. Deng, Q. Xiao, Q. He, G. Li, Y. Xia, M. Liu, C. Wang, Z. Fang, N. Xia, Z.-R. Zhang, B. Zhang, , B. Liu

This paper presents a subunit vaccine, PF-D-Trimer, derived from the Delta spike protein, showing robust immunogenicity and cross-reactive neutralizing antibodies against multiple SARS-CoV-2 variants.

bioRxiv · Sep 26, 2022Immunology

Omicron-specific mRNA vaccine elicits potent immune responses in mice, hamsters, and nonhuman primates

Y. Wu, Y. Shen, N. Wu, X. Zhang, S. Chen, C. Yang, J. Zhou, Y. Wu, D. Chen, L. Wang, Y. Wang, J. Xu, K. Liu, C. Wang, H. Zhang, , Y. Wang

This study develops an Omicron-specific mRNA vaccine that shows superior neutralizing antibody responses in mice, hamsters, and macaques compared to existing vaccines.

Cell Research · Aug 1, 2022Peer-reviewedMicrobiology

The porcine cGAS-STING pathway exerts an unusual antiviral function independent of IFN and autophagy

J. Zhu, S. Jiang, N. Xia, J. Luo, Y. Zhang, Q. Cao, J. Zhang, Y. Wang, W. Zheng, N. Chen, F. Meurens

This study shows porcine STING has antiviral activity independent of IFN and autophagy, and also triggers apoptosis to resist viral infections.

bioRxiv · Jul 28, 2022 · PreprintImmunology

A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-Cov-2 virus and Omicron variant through a unique binding mode

D. Zhao, L. Liu, X. Liu, J. Zhang, Y. Yin, L. Luan, D. Jiang, X. Yang, L. Li, H. Xiong, D. Xing, Q. Zheng, N. Xia, Y. Tao, S. Li, H. Huang

This paper reports a synthetic nanobody, C5G2, that neutralizes SARS-CoV-2 and Omicron variants with high potency through a unique binding mechanism.

bioRxiv · Apr 11, 2022 · PreprintBiochemistry

New efficient intercellular spread mode of respiratory syncytial virus contributes to neutralization escape and persistence

W. Zhang, X. Lin, L.-J. Zhang, L. Chen, Y.-P. Sun, J.-Y. Si, M. Zhao, G.-H. Wu, L.-T. Zhan, Y.-B. Wang, N. Xia, Z.-Z. Zheng

The paper identifies a new intercellular spread mode of RSV that is virion-independent and antibody-insensitive, contributing to immune escape and viral persistence.

bioRxiv · Feb 1, 2022 · PreprintMicrobiology

Molecular basis of broad neutralization against SARS-CoV-2 variants including Omicron by a human antibody

Z. Zhang, B. Ju, Q. Zheng, H. Guo, Q. Fan, T. Li, S. Song, H. Sun, S. Shen, X. Zhou, L. Cheng, W. Xue, L. Cui, B. Zhou, X. Ge, , N. Xia

A human antibody, VacW-209, broadly neutralizes SARS-CoV-2 variants including Omicron by targeting a conserved epitope, highlighting the importance of such antibodies in pandemic control.

bioRxiv · Jan 19, 2022 · PreprintImmunology

A live attenuated influenza virus-vectored intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2 infection

J. Chen, P. Wang, L. Yuan, L. Zhang, L. Zhang, H. Zhao, C. Chen, Y. Chen, J. Han, J. Jia, Z. Lu, J. Hong, L. Chen, C. Fan, Z. Lu, , N. Xia

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

bioRxiv · Nov 13, 2021Pathology

Urinary bladder enlargement across nine rodent models of diabetes: correlations with glucose and insulin levels

Z. E. Yesilyurt, J. Matthes, E. Hintermann, T. R. Castaneda, R. Elvert, J. H. Beltran-Ornelas, D. L. Silva-Velasco, N. Xia, A. Kannt, U. Christen, D. Centurion, H. Li, A. Pautz, E. Arioglu-Inan, M. C. Michel

The paper examines bladder enlargement in nine rodent diabetes models, finding variable enlargement and weak glucose correlations.

bioRxiv · Oct 25, 2021 · PreprintPharmacology & Toxicology

African swine fever virus structural protein p17 inhibits cGAS-STING signaling pathway through interacting with STING

W. Zheng, N. Xia, J. Luo, S. Jiang, J. Zhang, H. Wang, D. Ao, Y. Xu, X. Liu, Q. Shao, Q. Cao, Y. Zhang, N. Chen, Q. Zhang, J. Da, , J. Zhu

This study identifies p17 as a viral protein that inhibits the cGAS-STING pathway by interacting with STING and disrupting TBK1 and IKKε recruitment.

bioRxiv · Jun 2, 2021 · PreprintImmunology

The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε

J. Luo, J. Ni, S. Jiang, N. Xia, Y. Guo, Q. Shao, J. Zhang, Q. Cao, Z. Xu, W. Zheng, N. Chen, Q. Zhang, H. Chen, X. Guo, H. Zhu, , J. Zhu

This study identifies pS273R as an ASFV protease that inhibits the cGAS-STING pathway by targeting IKKε, revealing a new immune evasion mechanism.

bioRxiv · Jun 2, 2021Immunology

Quantatitive Analysis of Conserved Sites on the SARS-CoV-2 Receptor-Binding Domain to Promote Development of Universal SARS-Like Coronavirus Vaccines

S. Wang, D. Wu, H. Xiong, J. Wang, Z. Tang, Z. Chen, Y. Wang, Y. Zhang, D. Ying, X. Lin, C. Liu, S. Guo, W. Tian, Y. Lin, X. Zhang, , N. Xia

The paper identifies conserved antigenic sites in SARS-CoV-2 and SARS-CoV RBDs and designs RBD variants to improve immunogenicity for universal vaccine development.

bioRxiv · Apr 10, 2021 · PreprintImmunology

Sterilizing immunity against SARS-CoV-2 in hamsters conferred by a novel recombinant subunit vaccine

y. wu, X. Huang, L. Yuan, S. Wang, Y. Zhang, H. Xiong, R. Chen, J. Ma, R. Qi, M. Nie, J. Xu, Z. Zhang, L. Chen, M. Wei, M. Zhou, , N. Xia

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

bioRxiv · Dec 18, 2020 · PreprintMicrobiology

Robust neutralization assay based on SARS-CoV-2 S-bearing vesicular stomatitis virus (VSV) pseudovirus and ACE2-overexpressed BHK21 cells

H. Xiong, Y. Wu, J. Cao, R. Yang, J. Ma, X. Qiao, X. Yao, B. Zhang, Y. Zhang, W. Hou, Y. Shi, J. Xu, L. Zhang, S. Wang, B. Fu, , N. Xia

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

Emerging Microbes & Infections · Sep 24, 2020Peer-reviewedMicrobiology

Virus-free and live-cell visualizing SARS-CoV-2 cell entry for studies of neutralizing antibodies and compound inhibitors

Y. Zhang, S. Wang, Y. Wu, W. Hou, L. Yuan, C. Sheng, J. Wang, J. Ye, Q. Zheng, J. Ma, J. Xu, M. Wei, Z. Li, S. Nian, H. Xiong, , N. Xia

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

bioRxiv · Jul 22, 2020Microbiology

Room-temperature-storable PCR Mixes for SARS-CoV-2 Detection

J. Xu, J. Wang, Z. Zhong, X. Su, K. Yang, Z. Chen, D. Zhang, T. Li, Y. Wang, S. Zhang, S. Ge, J. Zhang, N. Xia

This paper develops freeze-dried PCR mixes for SARS-CoV-2 detection that can be stored at room temperature, maintaining sensitivity and specificity for up to 28 days.

bioRxiv · Apr 7, 2020 · PreprintMicrobiology

First Detection of Pathogenic Escherichia coli Isolates Associated With Donkey Foals' Diarrhea in Northern China

W.-q. LIU, N. XIA, J.-w. ZHANG, R. WANG, G.-m. JIANG

This study identifies pathogenic Escherichia coli isolates from donkey foals' diarrhea in Northern China, revealing virulence factors, antibiotic resistance, and genomic features.

bioRxiv · Apr 6, 2020 · PreprintPathology