F. Baldanti

Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages

Engineered dimeric and secretory IgA1 neutralized Omicron variants with higher potency than parental IgG.

Fourth dose of Microneedle Array Patch of SARS-CoV-2 S1 Protein Subunit Vaccine Elicits Robust Long-lasting Humoral Responses in mice

This study evaluates a microneedle array patch-based S1 subunit vaccine in mice, showing that four doses induce robust, long-lasting immune responses against multiple SARS-CoV-2 variants.

P-DOR, an easy-to-use pipeline to reconstruct outbreaks using pathogen genomics

P-DOR is a pipeline that uses pathogen genomics to reconstruct outbreaks by analyzing SNP-based phylogenies and metadata, providing a user-friendly tool for epidemiological investigations.

Tetravalent SARS-CoV-2 S1 Subunit Protein Vaccination Elicits Robust Humoral and Cellular Immune Responses in SIV-Infected Rhesus Macaque Controllers

This study evaluates a tetravalent SARS-CoV-2 S1 subunit vaccine in SIV-infected rhesus macaques, showing robust humoral and cellular immune responses, including cross-reactivity against Omicron.

Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2

The paper identifies broadly cross-reactive neutralizing antibodies against SARS-CoV-2 variants using coldspot-guided antibody discovery.

SARS-CoV-2 S1 Subunit Booster Vaccination Elicits Robust Humoral Immune Responses in Aged Mice

This study shows that a S1 subunit booster vaccine enhances neutralizing antibodies and cross-reactivity against multiple SARS-CoV-2 variants in aged mice vaccinated with an adenovirus-based vaccine.

Adenovirus-Vectored SARS-CoV-2 Vaccine Expressing S1-N Fusion Protein

This paper develops a novel adenovirus-vectored SARS-CoV-2 vaccine expressing S1-N fusion protein, showing improved immunogenicity in mice against SARS-CoV-2 variants.

Immunity to SARS-CoV-2 up to 15 months after infection

This study tracks SARS-CoV-2 immunity in patients up to 15 months post-infection, showing sustained antibody and memory B/T cell responses but reduced neutralization against variants.

Bispecific antibody neutralizes circulating SARS-CoV-2 variants, prevents escape and protects mice from disease

Neutrophil extracellular traps induce the epithelial-mesenchymal transition: implications in post-COVID-19 fibrosis

This study shows that neutrophil extracellular traps (NETs) induce epithelial-mesenchymal transition (EMT) in lung cells, contributing to post-COVID-19 fibrosis.

Persistence of SARS-CoV-2 specific B- and T-cell responses in convalescent COVID-19 patients 6-8 months after the infection

This study tracks SARS-CoV-2 specific B- and T-cell responses in convalescent patients 6-8 months post-infection, finding sustained memory cell responses despite declining antibody levels.

Performance assessment of Respiratory Viral ELITe MGB(R) assay for the quantitative detection of influenza A/B and respiratory syncytial viruses

The paper assesses the performance of a triplex PCR assay for detecting and quantifying influenza A/B and RSV, showing high agreement and correlation with in-house assays for FluA and RSV, but lower for FluB.

Human Cytomegalovirus Genomes Sequenced Directly from Clinical Material: Variation, Multiple-Strain Infection, Recombination and Mutation

The paper sequences HCMV genomes from clinical samples to study variation, multiple-strain infection, recombination, and mutation, finding that recombinant strains and pseudogenes can persist and cause congenital infections.