Author

W. Barclay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:host-pathogen & immune response· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Organism:chicken / avian· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Bhagwat· 1 shared A. C. Hurt· 1 shared A. D. S. Filipe· 1 shared A. Patel· 1 shared A. Pinto· 1 shared A. Saleh· 1 shared A.-M. Cujba· 1 shared C. J. Caceres· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperMicrobiology

A. Bhagwat

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding

J. Zou, M. Jiang, R. Xiao, H. Sun, H. Liu, T. Peacock, S. Tu, T. Chen, J. Guo, Y. Zhao, W. Barclay, S. Xie, H. Zhou

This study identifies GGCX as a key factor enabling EA H1N1 SIV adaptation to human-type -2,6 sialic acid receptors through HA carboxylation, suggesting it as a potential antiviral target.

bioRxiv · Mar 18, 2024Microbiology

Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning

G. R. Meehan, V. Herder, J. Allan, X. Huang, K. Kerr, D. C. Mendonca, G. Ilia, D. Wright, K. Nomikou, Q. Gu, S. M. Arias, G. De Lorenzo, V. Cowton, N. Upfold, N. Palmalux, , M. Palmarini

This study develops quantitative pipelines using digital pathology and machine learning to assess the virulence of SARS-CoV-2 variants in hamsters, showing that some Omicron sub-lineages have regained virulence.

bioRxiv · Aug 1, 2023Microbiology

The emergence of goblet inflammatory or ITGB6hi nasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

M. Woodall, A.-M. Cujba, K. B. Worlock, K.-M. Case, T. Masonou, M. Yoshida, K. Polanski, N. Huang, R. G. Lindeboom, L. Mamanova, L. Bolt, L. Richardson, S. Ellis, M. Palor, T. Burgoyne, , C. M. Smith

The study identifies age-related differences in nasal epithelial cell responses to SARS-CoV-2 infection, showing distinct progenitor cell dynamics in children and elderly.

bioRxiv · Jan 16, 2023 · PreprintCell Biology

Robustness of the ferret model for influenza risk assessment studies: a cross-laboratory exercise

J. A. Belser, E. H. Lau, W. Barclay, I. G. Barr, H. Chen, R. A. Fouchier, M. Hatta, S. Herfst, Y. Kawaoka, S. S. Lakdawala, L. Y. Y. Lee, G. Neumann, M. Peiris, D. R. Perez, C. J. Russell, , K. M. Septer

This study evaluates the consistency of ferret transmission experiments across laboratories for two H1N1 influenza viruses, finding concordant results and suggesting a minimum of three to five labs for reliable risk assessment.

bioRxiv · Apr 2, 2022Microbiology

SARS-CoV-2 variants of concern Alpha, Beta, Gamma and Delta have extended ACE2 receptor host-ranges

N. Thakur, G. Gallo, J. Newman, T. P. Peacock, L. Biasetti, C. N. Hall, E. Wright, W. Barclay, D. Bailey

The paper examines whether SARS-CoV-2 variants Alpha, Beta, Gamma, and Delta have altered ACE2 receptor usage across different mammalian species, finding that N501Y and E484K substitutions in the Spike RBD expand their host range.

bioRxiv · Nov 23, 2021Microbiology