Author

P. Dai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Bioengineering· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

L. Deng· 3 shared N. Yang· 3 shared Y. Wang· 3 shared A. A. Patel· 1 shared A. Ordureau· 1 shared A. Pinto· 1 shared A. Tan· 1 shared C. M. Rice· 1 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersImmunology

L. Deng

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Vaccinia E5 is a major inhibitor of the DNA sensor cGAS

N. Yang, Y. Wang, P. Dai, T. Li, C. Zierhut, A. Tan, T. Zhang, H. Pan, Z. Li, A. Ordureau, J. Z. Xiang, R. C. Hendrickson, H. Funabiki, Z. Chen, L. Deng

This study identifies Vaccinia E5 as a major inhibitor of the cGAS-STING pathway by promoting cGAS degradation through proteasome-dependent ubiquitination.

bioRxiv · Oct 25, 2021 · PreprintMicrobiology

Elucidating Mechanisms of Antitumor Immunity Mediated by Live Oncolytic Vaccinia and Heat-Inactivated Vaccinia

W. Wang, P. Dai, S. Liu, N. Yang, Y. Wang, R. A. Giese, T. Merghoub, J. D. Wolchok, L. Deng

This study compares the antitumor effects of live and heat-inactivated oncolytic vaccinia viruses and identifies immune mechanisms underlying their efficacy.

bioRxiv · Feb 11, 2021Immunology

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

D. Gao, F. Li, M. Han, P. Dai, W. Xu, J. He, X. Tao, Y. Wu, X. Tong, X. Xia, W. Guo, Y. Li, Y. Zhu, X. Zhang, Z. Liu, , Y. Zhou

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

bioRxiv · Sep 11, 2020Microbiology

The specialization of Esteya vermicola hyphae in infection to Bursaphelenchus xylophilus and its colonization of pine tree

H. Wang, C. Yin, J. Gao, R. Tao, P. Dai, C. Wang, C. SUNG

This paper investigates how Esteya vermicola colonizes pine trees and interacts with Bursaphelenchus xylophilus, revealing specific infection mechanisms and colonization patterns in healthy and infected trees.

bioRxiv · Aug 21, 2020 · PreprintPathology

Detecting and Quantitating Low Fraction DNA Variants with Low-Depth Sequencing

P. Song, S. X. Chen, Y. H. Yan, A. Pinto, L. Y. Cheng, P. Dai, A. A. Patel, D. Y. Zhang

This paper introduces mBDA, a method to detect low-frequency DNA variants with low-depth sequencing, and applies it to find tumor heterogeneity in melanoma samples.

bioRxiv · Apr 26, 2020 · PreprintBioengineering

Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against an acute vaccinia infection in the lungs

N. Yang, J. M. Luna, P. Dai, Y. Wang, C. M. Rice, L. Deng

The paper shows that lung type II alveolar epithelial cells induce IFN-beta and recruit CCR2+ monocytes to combat vaccinia virus infection.

bioRxiv · Jan 20, 2020Immunology