Q. Jia

Engineering oncogenic hotspot mutations on SF3B1 via CRISPR-directed PRECIS mutagenesis

This paper develops PRECIS, a method combining prime editing and a synthetic intron reporter to efficiently generate SF3B1 mutant cell lines that recapitulate cancer-related splicing and CNV events.

NaV1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8aN1768D/+ gain-of-function mice

The paper shows that inhibiting NaV1.6 reduces seizures in both wild-type and Scn8aN1768D/+ mice, suggesting NaV1.6 is a key target for anti-seizure drugs.

Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases

This study examines the coevolution of CDCA7, HELLS, and DNA methyltransferases, finding that their presence-absence patterns are non-random and linked across species.

Pneumococcal Evasion of Antibiotics via Metabolic Adaptation During Infection

This study shows that S. pneumoniae evades fluoroquinolone antibiotics through metabolic adaptation that reduces reactive oxygen species production, enabling tolerance and fitness restoration.

NBI-921352, a First-in-Class, Na V 1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in Scn8a Gain-of- Function Mice, and Wild-Type Mice and Rats

This paper describes NBI-921352, a selective NaV1.6 inhibitor that prevents seizures in Scn8a gain-of-function mice and wild-type models, with better efficacy and tolerability than existing antiseizure drugs.

Harringtonine has the effects of double blocking SARS-CoV-2 membrane fusion

This study shows Harringtonine inhibits SARS-CoV-2 membrane fusion by targeting both the viral S protein and host TMPRSS2, effectively blocking infection in delta and Omicron variants.

Competition Between Cell-Cell and Cell-Substrate Adhesion Determines Epithelial Monolayer Architecture in Culture

The paper investigates how cell-cell and cell-substrate adhesion balance determines epithelial monolayer architecture in cultured MDCK cells.

Salt-induced first-order structural transition in a DNA-interacting protein

This study investigates salt-induced structural transitions in the DNA-interacting protein SSB using magnetic tweezers and infrared spectroscopy, revealing discontinuous thermodynamic behavior at binding mode transitions.

Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV Spike pseudotyped virus

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.