R. Bhandari

Within-host adaptation of a foliar pathogen, Xanthomonas, on pepper in presence of quantitative resistance and ozone stress

This study examines how elevated ozone stress affects the eco-evolutionary dynamics of Xanthomonas perforans on resistant and susceptible pepper cultivars, revealing increased disease severity and pathogen population heterogeneity.

Interaction with IP6K1 supports pyrophosphorylation of substrate proteins by the inositol pyrophosphate 5-IP7

The paper shows that IP6K1 interacts with proteins that undergo pyrophosphorylation and with CK2, enabling coordinated pre-phosphorylation and pyrophosphorylation of target serine residues.

Biotic and abiotic stress distinctly drive the phyllosphere microbial community structure

The paper examines how biotic and abiotic stresses affect phyllosphere microbial communities in pepper plants, finding that elevated ozone alters microbial structure in resistant cultivars but not susceptible ones, and combined stress mimics pathogen effects.

CDDO-Methyl Ester Inhibits BRAF Inhibitor Resistance and Remodels the Myeloid Compartment in BRAF-mutant Melanoma

This study shows that CDDO-Methyl Ester reduces BRAF inhibitor resistance in melanoma by altering the tumor microenvironment and myeloid cell composition.

Glycoprotein VI is Critical for the Detection and Progression of Abdominal Aortic Aneurysms

This study identifies glycoprotein VI as a critical factor in AAA detection and progression, showing its predictive value in humans and therapeutic potential in mice.

Genetic and functional diversity help explain pathogenic, weakly pathogenic, and commensal lifestyles in the genus Xanthomonas

This study examines the genetic and functional diversity of Xanthomonas strains to understand their pathogenic, weakly pathogenic, and commensal lifestyles through genomic analysis and phylogenetic relationships.

Inositol hexakisphosphate kinase 1 is essential for cell junction integrity in the mouse seminiferous epithelium

This study shows that IP6K1 is essential for maintaining cell junction integrity in the mouse seminiferous epithelium, with its deletion causing BTB disruption and germ cell loss.

Probing metazoan polyphosphate biology using Drosophila reveals novel and conserved polyP functions

This study uses Drosophila to investigate polyphosphate (polyP) functions, revealing its role in hemolymph clotting and developmental timing, with implications for mammalian systems.

Pyrophosphoproteomics: extensive protein pyrophosphorylation revealed in human cell lines

This study identifies endogenous protein pyrophosphorylation in human cell lines using a tailored pyrophosphoproteomics workflow, revealing its role in rDNA transcription regulation.

Cellular, Molecular, and Enzymatic Signatures ofThrombi are Vascular Bed-Dependent

This study compares cellular and enzymatic features of arterial and venous thrombi from different vascular beds, finding distinct molecular profiles and enzyme activities linked to vascular remodeling.

Wheat inositol pyrophosphate kinase TaVIH2-3B modulates cell-wall composition for drought tolerance in Arabidopsis

This study identifies TaVIH2-3B, a wheat PPIP5K homolog, which enhances drought tolerance in Arabidopsis by modulating cell-wall composition through increased polysaccharide accumulation.

IP6K1 upregulates the formation of processing bodies by promoting proteome remodeling on the mRNA cap

This study shows IP6K1 promotes P-body formation by enhancing translation suppression through interactions with decapping and initiation complex proteins.

A pyro-phosphodegron controls MYC polyubiquitination to regulate cell survival

This study identifies a pyro-phosphodegron in MYC that regulates its polyubiquitination and degradation, affecting cell survival under stress and mitogenic conditions.