Increased chromatin accessibility mediated by nuclear factor I drives transition to androgen receptor splice variant dependence in castration-resistant prostate cancer
L. Poluben, M. Nouri, J. Liang, A. Varkaris, B. Ersoy-Fazlioglu, O. Voznesensky, I. Lee, X. Qiu, L. Cato, J.-H. Seo, M. Freedman, A. Sowalsky, N. Lack, E. Corey, P. Nelson, , S. Balk
This study shows that ARv7 drives AR activity in castration-resistant prostate cancer through increased chromatin accessibility mediated by NFI factors.
bioRxiv · Jan 10, 2024 · PreprintCancer Biology