Author

M. Freedman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

J.-H. Seo· 3 shared E. Corey· 2 shared M. Brown· 2 shared M. Pomerantz· 2 shared P. Nelson· 2 shared X. Qiu· 2 shared A. Dall'Agnese· 1 shared A. Farago· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

J.-H. Seo

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Author profile →

5 papers

Recent·Most cited

Increased chromatin accessibility mediated by nuclear factor I drives transition to androgen receptor splice variant dependence in castration-resistant prostate cancer

L. Poluben, M. Nouri, J. Liang, A. Varkaris, B. Ersoy-Fazlioglu, O. Voznesensky, I. Lee, X. Qiu, L. Cato, J.-H. Seo, M. Freedman, A. Sowalsky, N. Lack, E. Corey, P. Nelson, , S. Balk

This study shows that ARv7 drives AR activity in castration-resistant prostate cancer through increased chromatin accessibility mediated by NFI factors.

bioRxiv · Jan 10, 2024 · PreprintCancer Biology

Germline determinants of the prostate tumor genome

K. E. Houlahan, J. Yuan, T. Schwarz, J. Livingstone, N. S. Fox, W. Jaratlerdsiri, J. van Riet, K. Taraszka, N. Kurganovs, H. Zhu, J. Sietsma Penington, C.-H. Jung, T. N. Yamaguchi, J. Jiang, L. E. Heisler, , P. C. Boutros

The paper identifies germline-determined quantitative trait loci (dQTLs) that influence somatic mutational features in prostate cancer, revealing their impact on tumor epigenome, transcriptome, and proteome.

bioRxiv · Nov 16, 2022 · PreprintCancer Biology

Population-specific patterns of toxin sequestration in monarch butterflies from around the world

M. Freedman, S.-L. Choquette, S. Ramirez, S. Strauss, M. Hunter, R. Vannette

This study examines genetic variation in toxin sequestration in monarch butterflies across populations and host species, finding reduced sequestration in some populations under different ecological conditions.

bioRxiv · Oct 15, 2021 · PreprintEvolutionary Biology

Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate Cancer

P. Cejas, Y. Xie, A. Font-Tello, K. Lim, S. Symala, X. Qiu, A. Tewari, N. Shah, H. Nguyen, R. Patel, L. Brown, I. Coleman, W. M. Hackeng, L. Brosens, K. Dreijerink, , H. W. Long

This study identifies two distinct subtypes of neuroendocrine prostate cancer based on neuronal transcription factors and highlights their epigenetic convergence and therapeutic implications.

bioRxiv · Sep 13, 2020Cancer Biology

Genomic aberration based molecular signatures efficiently characterize homologous recombination deficiency in prostate cancer

Z. Sztupinszki, M. Diossy, M. Krzystanek, J. Borcsok, M. Pomerantz, V. Tisza, S. Spisak, O. Rusz, I. Csabai, M. Freedman, Z. Szallasi

The paper identifies genomic aberration-based molecular signatures to detect homologous recombination deficiency in prostate cancer, finding that 5-8% of cases may benefit from PARP-inhibitor treatment.

bioRxiv · Jun 24, 2019 · PreprintCancer Biology