I. Lee

Dual-mode action of scalable, high-quality engineered stem cell-derived SIRPα-extracellular vesicles for treating acute liver failure

This paper develops SIRPα-expressing extracellular vesicles from engineered stem cells to treat acute liver failure by resolving necroptosis and promoting liver regeneration, showing reduced liver damage and improved survival in models.

Chaperonin-mediated Winter Cold Response via Circadian Clock Components in Arabidopsis

The paper identifies chaperonin's role in regulating circadian clocks to mediate long-term cold responses in Arabidopsis, showing time-of-day-specific activation of cold response genes.

The complement regulator CD55 modulates TLR9 signaling and supports survival in marginal zone B cells

This study shows CD55 supports MZ B cell survival and regulates TLR9 signaling, with loss of CD55 leading to reduced survival and increased apoptosis in aged mice.

Increased chromatin accessibility mediated by nuclear factor I drives transition to androgen receptor splice variant dependence in castration-resistant prostate cancer

This study shows that ARv7 drives AR activity in castration-resistant prostate cancer through increased chromatin accessibility mediated by NFI factors.

Electrocatalytic on-site oxygenation for transplanted cell-based-therapies

This paper introduces an electrocatalytic system for on-site oxygen production to support cell therapies under hypoxic conditions.

Engineering a Single Extracellular Vesicle Protein and RNA Assay (siEVPRA) via In Situ Fluorescence Microscopy in a UV Micropatterned Array

The paper introduces siEVPRA, a method to detect proteins, mRNAs, and miRNAs in single EVs using fluorescence microscopy, showing high sensitivity and clinical utility in GBM samples.

HiFi Metagenomic Sequencing Enables Assembly of Accurate and Complete Genomes from Human Gut Microbiota

This study uses HiFi metagenomic sequencing to assemble 102 complete MAGs from human fecal samples, achieving high nucleotide accuracy and capturing previously unculturable microbial genomes.

Changes of small non-coding RNAs by severe acute respiratory syndrome coronavirus 2 infection

This study identifies changes in small non-coding RNAs (sncRNAs) in SARS-CoV-2 infection, showing that tRFs and a viral-derived sncRNA (sv-CoV2-346) are significantly altered.

MRGM: a mouse reference gut microbiome reveals a large functional discrepancy for gut bacteria of the same genus between mice and humans

The paper constructs a mouse reference gut microbiome (MRGM) and finds significant functional discrepancies between mouse and human gut bacteria of the same genus.

Vernalization-triggered expression of the antisense transcript COOLAIR is mediated by CBF genes

This study shows that CBF genes regulate COOLAIR expression during vernalization in Arabidopsis, but COOLAIR is not essential for the vernalization response.

Human reference gut microbiome comprising 5,414 prokaryotic species, including newly assembled genomes from under-represented Asian metagenomes

The paper expands the human gut microbiome reference database by incorporating newly assembled genomes from under-represented Asian populations, improving taxonomic and functional classification and revealing associations with autoimmunity.

Computational Study of Ions and Water Permeation and Transportation Mechanisms of the SARS-CoV-2 Pentameric E Protein Channel

This study investigates ion and water permeation mechanisms of the SARS-CoV-2 E protein channel using in silico methods, revealing hydrophobic gates and voltage-dependent behavior.

Prediction of LncRNA Encoded Small Peptides inGlioma and The Oligomer Channel Functional AnalysisUsing in Silico Approaches

This study predicts lncRNA-encoded small peptides in glioma and analyzes their oligomer channel function using in silico methods.

Traceback of Core Transcription Factors for Soybean Root Growth Maintenance under Water Deficit

The paper identifies core transcription factors regulating root growth in soybean under water deficit by integrating phylogenetic analysis and transcriptome data.

GHSR-1a is not Required for Ghrelin's Anti-inflammatory and Fat-sparing Effects in Cancer Cachexia

This study shows ghrelin prevents white adipose tissue inflammation and atrophy in cancer cachexia, but GHSR-1a is only needed for its appetite-stimulating effect.

Single-cell transcriptome analysis reveals TOX as a promoting factor for T-cell exhaustion and a predictor for anti-PD1 responses in human cancer

The paper identifies TOX as a factor promoting T-cell exhaustion and predicts its role in anti-PD1 therapy outcomes using single-cell transcriptome data from cancer patients.