K. Dean

A comprehensive model of Drosophila epithelium reveals the role of embryo geometry and cell topology in mechanical responses

The paper develops a model of Drosophila epithelium to show that mechanical responses depend on embryo geometry and cell topology, with apical surfaces being softer than basal ones.

Talin-vinculin precomplex drives adhesion maturation by accelerated force transmission and vinculin recruitment

The paper shows that talin's precomplex with vinculin accelerates adhesion maturation by enhancing vinculin recruitment and force transmission.

Extended depth of focus multiphoton microscopy via incoherent pulse splitting

The paper introduces a phase mask to extend depth of focus in multiphoton microscopy with minimal lateral resolution loss and demonstrates its effectiveness in imaging fixed brain samples.

A unified role for membrane-cortex detachment during cell protrusion initiation

The paper shows that membrane-cortex detachment is essential for initiating both pressure-based and actin-based protrusions, challenging the Brownian ratchet model and unifying protrusion regulation.

Light-sheet microscopy with isotropic, sub-micron resolution and solvent-independent large-scale imaging

This paper introduces ctASLM, a light-sheet microscopy technique with sub-micron isotropic resolution and large-scale imaging, enabling automated cell and subcellular feature detection in cleared tissues.

Amylase copy number analysis in several mammalian lineages reveals convergent adaptive bursts shaped by diet

The paper analyzes amylase copy number in mammals, finding convergent adaptive expansions linked to starch diets and increased enzymatic activity.