Author

K. Flaherty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

A. Sahu· 2 shared T. Nakamura· 2 shared A. Amzallag· 1 shared A. Andrescavage· 1 shared A. Enny· 1 shared A. Friedman· 1 shared A. Oubrie· 1 shared A. Shanabag· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

A. Sahu

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Author profile →

4 papers

Recent·Most cited

Distinct ossification trade-offs illuminate the shoulder girdle reconfiguration at the water-to-land transition.

J. Wei, T. W. P. Wood, K. Flaherty, A. Enny, A. Andrescavage, D. Brazer, D. Navon, T. A. Stewart, H. Cohen, A. Shanabag, S. Kuroda, I. Braasch, T. Nakamura

This study identifies Gli3's role in regulating ossification pathways in zebrafish pectoral girdles, revealing developmental trade-offs that may explain the evolution of tetrapod-like structures.

bioRxiv · Jul 17, 2023Evolutionary Biology

Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor Alpha

A. Sahu, X. Wang, P. Munson, J. Klomp, X. Wang, S. Gu, G. Qian, P. Nicol, Z. Zeng, C. Wang, C. Tokheim, W. Zhang, J. Fu, J. Wang, N. Nair, , K. Flaherty

BipotentR identifies immune-metabolic regulators for bipotent anticancer drugs, demonstrating ESRRA inhibition's effects on tumor metabolism and immune mechanisms.

bioRxiv · Oct 25, 2021 · PreprintCancer Biology

The evolutionary origins and diversity of the neuromuscular system of paired appendages in batoids

N. Turner, D. Mikalauskaite, K. Barone, K. Flaherty, G. Senevirathne, N. Adachi, N. Shubin, T. Nakamura

This study investigates the developmental and evolutionary origins of neuromuscular systems in batoid fish, finding that paired fin muscles evolved from redeployed genetic programs involved in dorsal fin development.

bioRxiv · May 21, 2019Evolutionary Biology

Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy

A. Sahu, J. Sang Lee, G. Zhang, Z. Wang, T. Tian, T. Moll, G. Kasumova, B. Miao, Z. Wei, N. U. Nair, O. Ponomarova, A. Friedman, A. Amzallag, P. Greninger, R. Egan, , E. Ruppin

The paper predicts synthetic rescue mediators of resistance to targeted and immunotherapy using tumor transcriptomics and survival data from 10,000 TCGA patients, validating predictions through experimental screens.

bioRxiv · Apr 8, 2018Cancer Biology