G. Chatta

Androgen deprivation triggers a cytokine signaling switch to induce immune suppression and prostate cancer recurrence

Developing folate-conjugated miR-34a therapeutic for prostate cancer treatment: Challenges and promises

This study evaluates folate-conjugated miR-34a as a potential prostate cancer therapeutic, finding limited efficacy due to low FOLR1 expression in prostate cancer cells.

Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells

The paper uses multi-omics single-cell data to define the epigenetic basis of castration-resistant prostate luminal cells in mice and identifies key molecular pathways involved.

Glucocorticoid signaling delays castration-induced regression in murine models of prostate cancer

This study shows that glucocorticoid signaling delays castration-induced regression in murine prostate cancer models by maintaining tumor proliferation through GR activation, which can be blocked by the GR antagonist relacorilant.

A circulating T-cell differentiation marker to predict response to immune checkpoint inhibitors

The paper identifies CX3CR1 expression on circulating CD8+ T cells as a biomarker predicting response to immune checkpoint inhibitor therapy in NSCLC patients.