Author

X. Jiao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2 Evolutionary Biology· 2 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Approach:statistical model· 5 Research Focus:differential expression· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

B. Rannala· 2 shared H. Qiao· 2 shared J. Lei· 2 shared T. Flouris· 2 shared Y. Zhang· 2 shared Z. Yang· 2 shared A. Gonsioroski· 1 shared B. Cui· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersEvolutionary Biology

B. Rannala

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Targeting CD74-positive macrophages improves neoadjuvant therapy in cervical cancer as revealed by single-cell transcriptomics analysis

Z. Wang, B. Wang, Y. Feng, J. Ye, Z. Mao, T. Zhang, M. Xu, W. Zhang, X. Jiao, Y. Zhang, B. Cui

This study uses single-cell transcriptomics to show that targeting CD74-positive macrophages enhances neoadjuvant therapy efficacy in cervical cancer by altering tumor microenvironment interactions.

bioRxiv · Nov 9, 2023 · PreprintCancer Biology

Quorum sensing inhibits Type III-A CRISPR-Cas system activity through repressing positive regulators SarA and ArcR in Staphylococcus aureus

Y. Li, X. Li, Y. Tang, N. M. Hoyland-Kroghsbo, H. Ingmer, X. Jiao, Q. Li

The paper shows quorum sensing represses the Type III-A CRISPR-Cas system in S. aureus by inhibiting SarA and ArcR, which are positive regulators of the system.

bioRxiv · Jan 17, 2023 · PreprintMicrobiology

Functional characterization of multidomain protein Vip3Aa from Bacillus thuringiensis reveals a strategy to increase its insecticidal potency

K. Jiang, Z. Chen, Y. Shi, X. Jiao, J. Cai, X. Gao

This study characterizes the functional domains of Vip3Aa protein from Bacillus thuringiensis and shows how modifying protease sites enhances its insecticidal potency against Spodoptera frugiperda larvae.

bioRxiv · Jul 14, 2022 · PreprintMicrobiology

Mechanism of treatment-free remission in patients with chronic myeloid leukemia revealed by a computational model of CML evolution

X. Lai, X. Jiao, H. Zhang, J. Lei

The paper develops a computational model to study the mechanisms of treatment-free remission in CML patients, revealing the role of the neoplastic microenvironment and leukemia stem cell dynamics.

bioRxiv · May 20, 2022 · PreprintCancer Biology

Individual cell-based modeling of tumor cell plasticity-induced immune escape after CAR-T therapy

C. Zhang, C. Shao, X. Jiao, Y. Bai, M. Li, H. Shi, J. Lei, X. Zhong

The paper develops a computational model to simulate tumor cell plasticity and immune escape after CAR-T therapy, finding that CAR-T stress induces tumor cells to transition into hematopoietic stem-like and myeloid-like cells, leading to relapse.

Computational and Systems Oncology · Sep 1, 2021Peer-reviewedCancer Biology

Perfluorononanoic acid impedes mouse oocyte maturation by inducing mitochondrial dysfunction and oxidative stress

X. Jiao, N. Liu, Y. Xu, H. Qiao

This study shows PFNA exposure impairs mouse oocyte maturation by causing spindle defects, mitochondrial dysfunction, oxidative stress, DNA damage, and apoptosis.

bioRxiv · Jul 6, 2021Cell Biology

Iodoacetic acid disrupts mouse oocyte maturation by inducing oxidative stress and spindle abnormalities

X. Jiao, A. Gonsioroski, J. A. Flaws, H. Qiao

This study shows that iodoacetic acid (IAA) disrupts mouse oocyte maturation by inducing oxidative stress, spindle abnormalities, and DNA damage.

bioRxiv · Sep 2, 2020Cell Biology

The Impact of Cross-Species Gene Flow on Species Tree Estimation

X. Jiao, T. Flouris, B. Rannala, Z. Yang

This study evaluates how gene flow affects species tree estimation methods and finds the majority-vote method is more robust than UPGMA and likelihood methods under gene flow scenarios.

bioRxiv · Oct 25, 2019Evolutionary Biology

A Bayesian implementation of the multispecies coalescent model with introgression for comparative genomic analysis

T. Flouris, X. Jiao, B. Rannala, Z. Yang

The paper implements a Bayesian model to infer introgression events using genomic data and applies it to study hybrid speciation in mosquito species.

bioRxiv · Sep 14, 2019Evolutionary Biology

“CapZyme-Seq” comprehensively defines promoter-sequence determinants for RNA 5’ capping with NAD+

I. O. Vvedenskaya, J. G. Bird, Y. Zhang, Y. Zhang, X. Jiao, I. Barvik, L. Krasny, M. Kiledjian, D. M. Taylor, R. H. Ebright, B. E. Nickels

The paper introduces CapZyme-Seq to detect NCIN-capped RNA and identifies a consensus promoter sequence for NAD+ capping in E. coli.

bioRxiv · Dec 29, 2017Biochemistry