Author

M. Bosmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:mouse· 7 Research Focus:host-pathogen & immune response· 6 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:spatial transcriptomics· 2 Research Focus:differential expression· 1

Frequent Co-Authors

C. Reinhardt· 4 shared F. Douam· 4 shared A. K. O'Connell· 3 shared D. Kenney· 3 shared M. Ericsson· 3 shared M. Saeed· 3 shared P. Montanaro· 3 shared A. Emili· 2 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersImmunology

C. Reinhardt

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Immunomodulation of Neutrophil Granulocyte Functions by Bacterial Polyphosphates

V. Krenzlin, J. Schoeche, S. Walachowski, C. Reinhardt, M. P. Radsak, M. Bosmann

This study shows that bacterial long-chain polyphosphates modulate neutrophil function, reducing inflammation and immune responses in mice and humans.

bioRxiv · Dec 21, 2022Immunology

Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1Omicron

D.-Y. Chen, D. Kenney, C.-V. Chin, A. H. Tavares, N. Khan, H. L. Conway, G. Liu, M. C. Choudhary, H. P. Gertje, A. K. O'Connell, D. N. Kotton, A. Herrmann, A. Ensser, J. H. Connor, M. Bosmann, , M. Saeed

This study compares the pathogenicity and immune evasion of an Omicron S-bearing virus with natural Omicron, showing vaccine escape via S mutations but severe disease due to factors outside S.

bioRxiv · Oct 13, 2022 · PreprintMicrobiology

Bacterial Polyphosphates Induce CXCL4 and Synergize with Complement Anaphylatoxin C5a in Lung Injury

J. Roewe, S. Walachowski, A. Sharma, K. A. Berthiaume, C. Reinhardt, M. Bosmann

This study shows that long-chain bacterial polyphosphates induce CXCL4 release from macrophages and synergize with C5a to cause lung injury.

bioRxiv · Jul 5, 2022Immunology

Proteome Microarray Screening Identifies Human Polyphosphate-Binding Proteins in the Phosphatidylinositol Signaling Pathway

V. Krenzlin, J. Roewe, M. Strueve, M. Martinez-Negro, C. Reinhardt, S. Morsbach, M. Bosmann

The paper identifies human polyphosphate-binding proteins using a proteome microarray screen, highlighting DAB1 and PIP4K2B in the phosphatidylinositol signaling pathway.

bioRxiv · Dec 10, 2021 · PreprintImmunology

Platelet proteome analysis reveals an early hyperactive phenotype in SARS-CoV-2-infected humanized ACE2 mice

S. Subramaniam, R. M. Hekman, A. Jayaraman, A. K. O'Connell, P. Montanaro, B. Blum, D. Kenney, M. Ericsson, K. Ravid, N. A Crossland, A. Emili, F. Douam, M. Bosmann

This paper uses proteomics to analyze platelet changes in SARS-CoV-2-infected humanized mice, finding early activation of coagulation and complement pathways.

bioRxiv · Aug 19, 2021 · PreprintImmunology

Macrophages govern antiviral responses in human lung tissues protected from SARS-CoV-2 infection

D. J. Kenney, A. K. O'Connell, J. Turcinovic, P. Montanaro, R. M. Hekman, T. Tamura, A. R. Berneshawi, T. R. Cafiero, S. Al Abdullatif, B. Blum, S. I. Goldstein, B. Heller, H. P. Gertje, E. Bullitt, A. J. Trachtenberg, , F. Douam

This study shows that macrophages mediate antiviral responses in human lung tissues, protecting against SARS-CoV-2 infection through the USP18-ISG15 axis.

bioRxiv · Jul 17, 2021 · PreprintMicrobiology

Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression

M. Carossino, P. Montanaro, A. O'Connell, D. Kenney, H. Gertje, K. Grosz, M. Ericsson, B. R. Huber, S. Subramaniam, T. A. Kirkland, J. R. Walker, K. P. Francis, A. D. Klose, N. Paragas, S. Kurnick, , N. Crossland

This study investigates SARS-CoV-2 infection in K18-hACE2 mice, showing neuroinvasion and neuronal injury are key to lethality, with viral tropism not fully dependent on hACE2 expression.

bioRxiv · Jan 13, 2021 · PreprintPathology

IL-27 enhances the lymphocyte mediated innate resistance to primary hookworm infection in the lungs

J. B. Noon, A. Sharma, J. Platten, L. J. Quinton, C. Reinhardt, M. Bosmann

This study shows IL-27 reduces hookworm infection and lung damage by enhancing lymphocyte responses in mice.

bioRxiv · Aug 12, 2020 · PreprintImmunology