M. Chao

CD4+ T cells are homeostatic regulators during Mtb reinfection

The paper shows that CD4+ T cells reduce inflammation and disease severity during Mtb reinfection by reprogramming CD8+ T cells and innate immune cells.

Antibiotic treatment does not abrogate protection against Mycobacterium tuberculosis reinfection

This study shows antibiotic treatment after primary Mtb infection reduces lung inflammation but does not eliminate protection against reinfection in macaques.

Heat wave event facilitates defensive responses in invasive C3 plant Ambrosia artemisiifolia L. under elevated CO2 concentration to the detriment of insect herbivores

The paper examines how heat waves and elevated CO2 affect Ambrosia artemisiifolia growth, secondary metabolism, and its impact on leaf beetles, showing enhanced plant defenses and reduced herbivore performance.

Age-related Impairment of Implant Osseointegration is Associated with Immune Activation and Suppression of Angiogenic, Notch, and Wnt Pathways

This study identifies age-related downregulation of angiogenic, Notch, and Wnt pathways in peri-implant tissue, linked to immune activation and impaired osseointegration in aged mice.

Multimodal profiling of lung granulomas reveals cellular correlates of tuberculosis control

The paper identifies cellular and temporal factors associated with bacterial control in tuberculosis granulomas using multimodal data.

Single-Cell Map of Diverse Immune Phenotypes in the Metastatic Brain Tumor Microenvironment of Non Small Cell Lung Cancer

The paper uses single-cell RNA sequencing to analyze immune cell composition in brain metastases of NSCLC patients, finding reduced T cell activity and expanded M2-polarized tumor-associated macrophages.