M. Kelm

Crosstalk between thrombospondin-1 and CD36 modulates platelet-RBC interaction limiting thrombosis and abdominal aneurysm formation

This study identifies a novel CD36-TSP-1 signaling pathway that modulates platelet-RBC interaction, promoting thrombus formation and contributing to abdominal aortic aneurysm pathology.

Using TCR and BCR sequencing to unravel the role of T and B cells in abdominal aortic aneurysm

This study uses scRNA TCR and BCR sequencing to analyze T and B cell responses in murine AAA, finding no clonal expansion of TCRs or BCRs.

Inhibition of proline-rich-tyrosine kinase 2 restores cardioprotection by remote ischemic preconditioning in type 2 diabetes mellitus

This study shows that inhibiting Pyk2 restores cardioprotection lost in diabetes through improved endothelial function and eNOS activity during remote ischemic preconditioning.

Inhibition of CD40-TRAF6 signaling protects against aneurysm development and progression

This study shows that inhibiting CD40-TRAF6 signaling reduces abdominal aortic aneurysm severity and progression in mice.

Quantitative assessment of angioplasty induced vascular inflammation with 19F cardiovascular magnetic resonance imaging

This study uses 19F MRI to quantify monocyte/macrophage infiltration after vascular injury with sufficient sensitivity.

Platelet pannexin-1 channels modulate inflammation during abdominal aortic aneurysm formation

This study investigates the role of platelet pannexin-1 channels in inflammation during abdominal aortic aneurysm formation and finds that their modulation does not affect AAA progression.

Ageing impairs the neuro-vascular interface in the heart

This study shows aging reduces nerve density in the left ventricle and dysregulates neuro-regulatory genes, leading to reduced heart rate variability.