N. Gerdes

Novel fluorescence-based methods to determine infarct and scar size in murine models of reperfused myocardial infarction

The paper compares fluorescence staining methods to classical histochemical techniques for determining infarct and scar size in murine reperfused myocardial infarction models.

Crosstalk between thrombospondin-1 and CD36 modulates platelet-RBC interaction limiting thrombosis and abdominal aneurysm formation

This study identifies a novel CD36-TSP-1 signaling pathway that modulates platelet-RBC interaction, promoting thrombus formation and contributing to abdominal aortic aneurysm pathology.

Inhibition of CD40-TRAF6 signaling protects against aneurysm development and progression

This study shows that inhibiting CD40-TRAF6 signaling reduces abdominal aortic aneurysm severity and progression in mice.

Using TCR and BCR sequencing to unravel the role of T and B cells in abdominal aortic aneurysm

This study uses scRNA TCR and BCR sequencing to analyze T and B cell responses in murine AAA, finding no clonal expansion of TCRs or BCRs.

Deficiency in hyaluronan synthase 3 attenuates ruptures in a murine model of abdominal aortic aneurysms by reduced aortic monocyte infiltration

This study shows that deficiency in HAS3 reduces aortic ruptures in a murine AAA model by decreasing monocyte infiltration and ECM degradation.

Quantitative assessment of angioplasty induced vascular inflammation with 19F cardiovascular magnetic resonance imaging

This study uses 19F MRI to quantify monocyte/macrophage infiltration after vascular injury with sufficient sensitivity.

Inhibition of myeloperoxidase prevents thoracic aortic aneurysm formation in Marfan mice

This study shows that inhibiting myeloperoxidase prevents thoracic aortic aneurysms in Marfan mice by reducing inflammation and extracellular matrix damage.

Platelet pannexin-1 channels modulate inflammation during abdominal aortic aneurysm formation

This study investigates the role of platelet pannexin-1 channels in inflammation during abdominal aortic aneurysm formation and finds that their modulation does not affect AAA progression.

Single-cell transcriptomics defines heterogeneity of epicardial cells and fibroblasts within the infarcted heart

The paper uses single-cell RNA sequencing to identify distinct epicardial stromal cell populations in infarcted mouse hearts and their potential cardiomyogenic properties.