Author

C. Le

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Organism:bacteria (other)· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

B. Nishimura· 2 shared C. Pimentel· 2 shared M. R. Tuttobene· 2 shared M. S. Ramirez· 2 shared M. Tolmasky· 2 shared R. A. Bonomo· 2 shared T. Subils· 2 shared A. Carranza· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersMicrobiology

B. Nishimura

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Global atlas of predicted functional domains in Legionella pneumophila Dot/Icm translocated effectors

D. T. Patel, P. J. Stogios, L. Jaroszewski, M. L. Urbanus, M. Sedova, C. Semper, C. Le, A. Takkouche, K. Ichii, J. Innabi, D. H. Patel, A. W. Ensminger, A. Godzik, A. Savchenko

The paper provides a global atlas of predicted functional domains in Legionella pneumophila effectors using 3D structure prediction, identifying novel domains and demonstrating their functional impact.

bioRxiv · May 9, 2024Microbiology

Evolutionary fingerprints of EMT in pancreatic cancers

L. Perelli, L. Zhang, S. Mangiameli, A. J. C. Russell, F. Giannese, F. Peng, F. Carbone, C. Le, H. Khan, F. Citron, M. Soeung, T. Lam, S. Lundgren, C. Zhu, D. Catania, , G. Genovese

This study investigates the role of EMT in pancreatic cancer evolution and metastasis, showing that mesenchymal lineages drive chromosomal instability and clonal evolution.

bioRxiv · Sep 18, 2023 · PreprintCancer Biology

Rigosertib promotes anti-tumor immunity via autophagic degradation of PD-L1 in colorectal cancer cells

X. Zhou, D. Fu, H. Yang, C. Le, Y. Lu, J. Wei, Y. Tang, J. Zhang, Y. Yuan, K. Ding, Q. Xiao

Rigosertib promotes anti-tumor immunity by inducing autophagic degradation of PD-L1 in colorectal cancer cells, enhancing immune response and synergizing with checkpoint inhibitors.

bioRxiv · Feb 7, 2023Cancer Biology

Impact of Human Serum Proteins on Susceptibility of Acinetobacter baumannii to Cefiderocol: role of iron transport

C. Le, C. Pimentel, F. Pasteran, M. R. Tuttobene, T. Subils, J. Escalante, B. Nishimura, S. Arriaga, A. Carranza, A. J. Vila, A. Corso, L. A. Actis, M. Tolmasky, R. A. Bonomo, M. S. Ramirez

The paper shows that human serum and its components increase Acinetobacter baumannii resistance to cefiderocol by altering iron uptake and beta-lactam resistance genes.

bioRxiv · Aug 18, 2021Microbiology

Interplay between meropenem and human serum albumin on expression of carbapenem resistance genes and natural competence in Acinetobacter baumannii

C. Pimentel, C. Le, M. R. Tuttobene, T. Subils, B. Nishimura, G. M. Traglia, F. Perez, K. M. Papp-Wallace, R. A. Bonomo, M. Tolmasky, M. S. Ramirez

This study shows that human serum albumin and meropenem together enhance natural transformation and gene expression in Acinetobacter baumannii, potentially promoting resistance and evolution.

bioRxiv · May 14, 2021Microbiology

Novel pipeline of high-frequency neoantigens heathy donor-based validation in breast cancer

Q. li, H. ying, L. duan, L. geng, L. mei, A. ting, L. li, C. le, L. bo

The paper develops a computational pipeline to identify high-frequency neoantigens in breast cancer and validates their immunogenicity using healthy donor blood samples.

bioRxiv · Apr 4, 2019 · PreprintCancer Biology