F. Wan

Molecular de-extinction of antibiotics enabled by deep learning

This paper introduces a deep learning method to discover antibiotic peptides from extinct organisms, identifying novel sequences with antimicrobial activity not found in modern species.

A novel bacterial signal transduction system specifically senses and responds to peptidoglycan damage

This study identifies a bacterial two-component system that detects and responds to peptidoglycan damage, revealing its role in antibiotic resistance and tolerance.

Adipokine C1q/Tumor necrosis factor-related protein 3 (CTRP3) Attenuates Intestinal Inflammation via Histone Deacetylase Sirtuin 1 (SIRT1)/NF-κB Signaling

This study shows that CTRP3 reduces intestinal inflammation in colitis models and IBD patients by modulating SIRT1/NF-κB signaling to suppress pro-inflammatory cytokines.

AHR agonist ITE boosted PD1 antibodys effects by inhibiting myeloid-derived cells suppressive cells in an orthotopic mouse glioma model

The paper shows that ITE, an AHR agonist, enhances PD1 antibody efficacy in a glioma model by reducing MDSCs and increasing CD8+ T cell infiltration.

A Community Challenge for Pancancer Drug Mechanism of Action Inference from Perturbational Profile Data

The paper hosts a DREAM Challenge to evaluate computational models for predicting drug polypharmacology using perturbational profile data from 32 kinase inhibitors.

Decreased miR-24-3p potentiates DNA damage responses and increases susceptibility to COPD

The paper identifies miR-24-3p as a regulator of DNA damage responses and COPD susceptibility, showing its suppression in COPD and its role in modulating apoptosis and DNA repair.

Targeting Aryl Hydrocarbon Receptor with small molecule, 1'H-indole-3'-carbonyl -thiazole-4-carboxylic acid methyl ester blocked human glioma cell invasion via MYH9

The paper shows that ITE, an AHR ligand, inhibits glioma cell migration and invasion by reducing MYH9 expression, which is critical for cell motility.

sgRNA level is a major factor affecting CRISPRi knockdown efficiency in K562 cells

This study shows that sgRNA expression level is a major determinant of CRISPRi knockdown efficiency in K562 cells, more impactful than KRAB-dCas9 expression level.

Crowdsourced mapping of unexplored target space of kinase inhibitors

The paper benchmarks predictive models for kinase inhibitor potencies using crowdsourced data and identifies new compound-kinase interactions.