N. Kaminski

CD103+ Dendritic Cell - Fibroblast Crosstalk via TLR9 and AHR Signaling Drives Lung Fibrogenesis

This study identifies CD103+ dendritic cell-fibroblast crosstalk via TLR9 and AHR signaling as a driver of lung fibrosis in IPF, showing that inhibiting AHR signaling reduces fibrosis.

Mast-Cell Expressed Membrane Protein-1 (MCEMP1) is expressed in classical monocytes and alveolar macrophages in Idiopathic Pulmonary Fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFβ dependent manner.

This study identifies MCEMP1 as highly expressed in monocytes and macrophages in IPF, regulated by TGFβ and involved in chemotaxis, adhesion, and migration through RHO GTPase modulation.

Single-cell transcriptomic analysis of human pleura reveals stromal heterogeneity and informs in vitro models of mesothelioma

This study presents a single-cell transcriptomic atlas of human pleura, identifying stromal heterogeneity and informing in vitro models of mesothelioma.

Spatiotemporal coordination of stem cell behavior following alveolar injury

This study tracks alveolar type 2 stem cell behavior after injury using live imaging and identifies distinct motility states and their regulation.

In vitro engineering of the lung alveolus

This study develops an in vitro strategy to engineer lung alveoli by coordinating biochemical, cellular, and mechanical cues to differentiate alveolar epithelial cells.

High CXCL6 drives matrix expression and correlate with markers of poor outcome in IPF

This study identifies CXCL6 as a pro-fibrotic factor in IPF, showing it reduces cAMP, increases collagen and -SMA, and correlates with poor patient survival.

Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

This study shows that pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis by promoting bone-type cross-linking and increasing tissue stiffness.

Single Cell RNA-seq and Mass Cytometry Reveals a Novel and a Targetable Population of Macrophages in Idiopathic Pulmonary Fibrosis

The paper identifies a novel, targetable macrophage population in idiopathic pulmonary fibrosis using single-cell RNA-seq, CyTOF, and flow cytometry.

Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T cells

This study identifies IFN-I-regulated co-inhibitory receptor expression in human T cells through transcriptional networks and single-cell RNA-sequencing in SARS-CoV-2 infection.

Integrated Single Cell Atlas of Endothelial Cells of the Human Lung

The paper reanalyzes six scRNA-seq datasets to create a comprehensive reference atlas of human lung endothelial cells, identifying new subpopulations and confirming their conservation in mice.

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity

The paper analyzes single-cell transcriptomes from healthy and chronic lung disease lungs to identify gene expression programs linked to SARS-CoV-2 entry and severity.

Airway Basal Cells show a dedifferentiated KRT17high Phenotype and promote Fibrosis in Idiopathic Pulmonary Fibrosis

This study identifies IPF-ABC as dedifferentiated KRT17high cells that promote fibrosis and shows SRC inhibition can reverse their profibrotic effects.

Decreased miR-24-3p potentiates DNA damage responses and increases susceptibility to COPD

The paper identifies miR-24-3p as a regulator of DNA damage responses and COPD susceptibility, showing its suppression in COPD and its role in modulating apoptosis and DNA repair.