M. Shang

Phage-Encoded Bismuth Bicycles: Instant Access to Targeted Bioactive Peptides

This paper introduces a method to create bicyclic peptides using bismuth and arsenic in phage display, showing improved binding affinity over linear peptides.

Deleterious Mechanical Deformation Selects Mechanoresilient Cancer Cells with Enhanced Proliferation and Chemoresistance

The paper shows that mechanical deformation selects for cancer cells with enhanced proliferation and chemoresistance, linking physical microenvironmental barriers to metastatic malignancy.

Two-color super-resolution localization microscopy via joint encoding of emitter location and color

This paper introduces a two-color super-resolution microscopy method using an RGBW camera and joint encoding of emitter location and color, achieving ~20 nm resolution and <2% crosstalk.

Pharmacological inhibition of PAI-1 alleviates cardiopulmonary pathologies induced by exposure to air pollutants PM2.5

This study shows that inhibiting PAI-1 with TM5614 reduces PM2.5-induced cardiopulmonary and vascular damage in both in vivo and in vitro models.

Reduced virulence and enhanced host adaption during antibiotics therapy: A story of a within-host carbapenem-resistant Klebsiella pneumoniae sequence type 11 evolution in a fatal scrotal abscess patient

This study tracks the genomic evolution of ST11-CRKP during antibiotic therapy in a patient, identifying mutations linked to reduced virulence and increased host adaptation.

Anti-inflammatory properties of chemical probes in human whole blood: focus on prostaglandin E2 production

The paper screens chemical probes in human whole blood to assess their effect on PGE2 and IL-8 production, identifying MEK inhibitors as anti-inflammatory and JAK inhibitor as pro-inflammatory.