P. Puigserver

Cardiomyocyte PGC-1α enables physiological adaptations to endurance exercise through suppression of GDF15 and cardiac atrophy

This study shows that cardiomyocyte PGC-1α is essential for cardiac adaptation to endurance exercise by suppressing GDF15 and preventing cardiac atrophy in mice.

Structural basis of respiratory complexes adaptation to cold temperatures

This study identifies a cold-induced conformation of respiratory complex CI:III2 using cryo-EM and simulations, revealing structural changes that enhance electron transfer efficiency in cold environments.

Selective Mitochondrial Respiratory Complex I Subunit Deficiency Causes Tumor Immunogenicity

This study shows that deleting specific mitochondrial Complex I subunits, Ndufs4 and Ndufs6, enhances tumor immunogenicity and sensitivity to immune checkpoint blockade in mouse melanoma models.

Tetracycline-dependent inhibition of mitoribosome protein elongation in mitochondrial disease mutant cells suppresses IRE1α to promote cell survival

The paper shows tetracyclines suppress IRE1α in mitochondrial disease cells by inhibiting mitoribosome elongation, promoting survival during glucose starvation.

A liver-specific mitochondrial carrier that controls gluconeogenesis and energy expenditure

This study identifies SLC25A47 as a liver-specific mitochondrial carrier that regulates gluconeogenesis and energy expenditure by controlling pyruvate flux and FGF21 expression.