D. Gao

Bacillus velezensis HBXN2020 alleviates Salmonella Typhimurium infection in mice by improving intestinal barrier integrity and reducing inflammation

This study shows that Bacillus velezensis HBXN2020 reduces Salmonella Typhimurium infection in mice by enhancing intestinal barrier function and decreasing inflammation.

USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase transition potential

This study identifies USP10 as a novel regulator of β-catenin through dual mechanisms involving deubiquitination and phase separation, with implications for cancer treatment.

Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer

The paper identifies adeno-to-squamous transition (AST) as a mechanism of resistance to KRAS inhibitors in LKB1 mutant lung cancer and links KRT6A expression to poor patient outcomes.

TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling.

This study shows TLR2 regulates hair follicle cycles and regeneration through BMP signaling, with reduced TLR2 and its ligand linked to hair loss in aging and obesity.

BNIP3-mediated mitophagy boosts the competitive dominant growth of lenvatinib resistant cells via reprogramming energy metabolism in HCC

This study identifies BNIP3-mediated mitophagy as a mechanism enhancing lenvatinib-resistant HCC cells' competitive growth through energy metabolism reprogramming.

Targeting Ribosome Biogenesis as a Novel Therapeutic Approach to Overcome EMT-related Chemoresistance in Breast Cancer.

This study identifies ribosome biogenesis as a key driver of EMT/MET transitions in breast cancer and shows that targeting this pathway enhances chemotherapy efficacy against chemoresistant tumors.

The Evidence of Cough Contagion in Human Beings

This study provides evidence that cough contagion in humans is driven by empathy, not physiology, showing no time difference and gender-based susceptibility.

Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis

The paper identifies TAZ as a molecular switch driving phenotypic transition and metastasis in SCLC by analyzing mouse models and human data.

Genomic rearrangements have consequences for introgression breeding as revealed by genome assemblies of wild and cultivated lentil species

The paper develops genome assemblies of wild and cultivated lentil species to reveal structural rearrangements affecting introgression breeding.

Structure of Infective Getah Virus at 2.8 A-resolution Determined by Cryo-EM

The paper determines the structure of infective Getah virus at 2.8 Å resolution using cryo-EM, revealing glycosylation, S-acylation sites, and lipid interactions critical for immune evasion and host cell invasion.

Co3O4 /PAn Magnetic Nanoparticle-Modified Electrochemical Immunosensor for Azocyclotin

The paper develops an electrochemical immunosensor for detecting azocyclotin residues using Co3O4/PAn nanoparticles, achieving good sensitivity and accuracy in agricultural samples.

Chromatin accessibility profiles of castration-resistant prostate cancers reveal novel subtypes and therapeutic vulnerabilities

This study identifies four subtypes of castration-resistant prostate cancer using ATAC-seq and RNA-seq data, revealing novel therapeutic targets and classification for 370 patients.

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

ERG orchestrates chromatin interactions to drive prostate cell fate reprogramming

The paper identifies ERG's role in prostate cancer by showing it inhibits basal cell differentiation through chromatin interactions, promoting luminal cell fate.

Development of A Novel Highly Selective TLR8 Agonist for Cancer Immunotherapy

This paper describes the development of DN052, a novel TLR8 agonist with high potency and selectivity, showing strong antitumor activity and favorable safety profile, leading to phase I clinical trials.

Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak

This study estimates the basic reproduction number (R0) of 2019-nCoV in China during the early outbreak phase using exponential growth modeling and serial intervals from similar coronaviruses.

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.

Cryopreservation of human mucosal tissues

This study compares cryopreservation and vitrification protocols for human mucosal tissues, finding cryopreservation effective for cervicovaginal tissues but less so for colorectal tissues.

phospho-ERK is a response biomarker to a combination of sorafenib and MEK inhibition in liver cancer

This study identifies phospho-ERK as a biomarker for response to sorafenib and MEK inhibition in liver cancer, showing synergistic effects in tumors with high phospho-ERK levels.