Author

R. Casellas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

A. Conte· 2 shared A. Y. Ye· 2 shared F. Muecksch· 2 shared F. W. Alt· 2 shared J. Lieberman· 2 shared J. Lou· 2 shared J. Xu· 2 shared P. D. Bieniasz· 2 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

A. Conte

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Multimeric nanobodies from camelid engineered mice and llamas potently neutralize SARS-CoV-2 variants

J. Xu, K. Xu, S. K. Jung, A. Conte, J. Lieberman, F. Muecksch, J. C. C. Lorenzi, S. Park, Z. Wang, L. Tessarollo, T. Bylund, G.-Y. Chuang, A. Olia, I.-T. Teng, T. Zhou, , R. Casellas

This paper isolates and characterizes nanobodies from camelids and engineered mice that neutralize SARS-CoV-2 variants through conserved epitopes and multimeric avidity.

bioRxiv · Mar 4, 2021 · PreprintImmunology

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

Z. Wang, F. Schmidt, Y. Weisblum, F. Muecksch, C. O. Barnes, S. Finkin, D. Schaefer-Babajew, M. Cipolla, C. Gaebler, J. A. Lieberman, T. Y. Oliveira, Z. Yang, M. E. Abernathy, K. E. Huey-Tubman, A. Hurley, , M. C. Nussenzweig

This study examines antibody and memory B cell responses to mRNA vaccines against SARS-CoV-2 and assesses their effectiveness against emerging variants.

Nature · Feb 10, 2021Peer-reviewedImmunology

Structure of the Mammalian Mediator

H. Zhao, N. Young, J. Kalchschmidt, J. Lieberman, L. El Khattabi, R. Casellas, F. J. Asturias

This study presents a molecular model of mammalian Mediator complex using cryo-EM, revealing the structure of the previously unresolved Tail module and its interactions with core Mediator.

bioRxiv · Oct 5, 2020 · PreprintCell Biology

Loop Extrusion Mediates Physiological Locus Contraction for V(D)J Recombination

H.-Q. Dai, H. Hu, J. Lou, A. Y. Ye, A. M. Chapdelaine-Williams, N. Kyritsis, Y. Zhang, N. Manfredonia, R. Judson, H. Chen, K. Johnson, S. Lin, Z. Ba, A. Conte, R. Casellas, , F. W. Alt

The paper shows that locus contraction and V(D)J recombination are regulated by circumventing CBE scanning impediments through Wapl-dependent cohesin dynamics.

bioRxiv · Jun 30, 2020 · PreprintImmunology

CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning

Z. Ba, J. Lou, E. W. Dring, A. Y. Ye, S. G. Lin, S. Jain, K.-R. Kieffer-Kwon, R. Casellas, F. W. Alt

This study shows that CTCF degradation promotes distal VH-to-DJH joining by enabling cohesin-driven RAG-scanning in pro-B cells.

bioRxiv · Jan 1, 2020Immunology