J. Mao

Holistic inference explains human perception of stimulus orientation

The paper introduces a holistic inference model for stimulus orientation perception, showing it accurately describes human responses better than previous models.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

VGLL2 and TEAD1 fusion proteins drive YAP/TAZ-independent tumorigenesis by engaging p300

This study identifies VGLL2 and TEAD1 fusion proteins as YAP/TAZ-independent drivers of tumorigenesis by recruiting p300 for epigenetic regulation.

Co-Occurrence Network Analysis Reveals The Alterations Of The Skin Microbiome And Metabolome In Atopic Dermatitis Patients

This study analyzes the skin microbiome and metabolome in healthy and atopic dermatitis patients to identify microbial and metabolic changes associated with the disease.

Comprehensive multi-platform tyrosine kinase profiling reveals novel actionable FGFR aberrations across pediatric and AYA sarcomas

The paper identifies FGFR aberrations as actionable targets in pediatric and AYA sarcomas using multi-platform profiling and shows FGFR inhibitors can inhibit tumor growth in PDX models.

De Novo Design of Peptide Binders to Conformationally Diverse Targets with Contrastive Language Modeling

This paper designs short, target-binding linear peptides using a contrastive learning framework, demonstrating effective binding and degradation of conformationally diverse proteins.

Structural Visualization of HECT-type E3 ligase Ufd4 Accepting and Transferring Ubiquitin to Form K29/K48-branched Polyubiquitination

This study determines the structural mechanism of HECT-type E3 ligase Ufd4 in catalyzing K29/K48-branched polyubiquitination by capturing structural snapshots of Ub transfer cascades.

Cryo-EM structure of DNA polymerase θ helicase domain in complex with inhibitor novobiocin

The paper presents the Cryo-EM structure of DNA polymerase θ helicase domain with and without inhibitor novobiocin, revealing a non-canonical binding pocket and insights into its mechanism.

Highly synchronized cortical circuit dynamics mediate spontaneous pain

This study shows that spontaneous pain induces synchronized neural dynamics in the primary somatosensory cortex, and reversing this synchronization alleviates pain.

Selective degradation of an ER stress-induced protein by ER-associated degradation mechanism during stress recovery

The paper shows that TIN1, an ER stress-induced protein in Arabidopsis, is selectively degraded by the ERAD complex during stress recovery, while other UPR-induced proteins remain stable.

Discovery of a new class of reversible TEA-domain transcription factor inhibitors with a novel binding mode

This paper identifies a new class of TEAD-YAP inhibitors with a novel binding mode that suppresses transcriptional activity and shows anti-proliferative effects in cancer cells.

Comparison of proton transfer paths to the QA and QB sites of the Rb. sphaeroides photosynthetic reaction centers

The paper compares proton transfer paths to the QA and QB sites in Rb. sphaeroides reaction centers using molecular dynamics, finding QA is isolated while QB has a complex network involving multiple surface residues.

Highly efficient multiplex genome editing in dicot plants using improved CRISPR/Cas systems

This study improves CRISPR/Cas9 systems for efficient gene editing in dicot plants, achieving over 80% homozygous/bi-allelic mutations in tobacco and tomato.

Characterizing protein protonation microstates using Monte Carlo sampling

The paper characterizes protonation microstates of proteins using Monte Carlo sampling, showing energy differences and correlations between residues in different pH conditions and reaction intermediates.

Effect of water temperature on the behavior of Neptunea cumingii and the histology, immune enzyme activity, and transcriptome of its gills and kidneys

This study examines how temperature affects the behavior and molecular responses of Neptunea cumingii, showing significant physiological and transcriptomic changes outside the optimal temperature range of 8–16°C.

Structural Insights Into the Initiation and Elongation of Ubiquitination by Ubr1

This study reports cryo-EM structures of Ubr1 complexes to elucidate the mechanism of ubiquitination initiation and elongation using a single E2 enzyme.

THE URINARY MICROBIOME IN POSTMENOPAUSAL WOMEN WITH RECURRENT URINARY TRACT INFECTIONS

This study compares the urinary microbiome in postmenopausal women with and without recurrent UTIs, finding no significant differences in Lactobacillus abundance but identifying anaerobic taxa differences associated with UTI recurrence.

Blue sky’s the limit? Somatic embryogenesis as a means of propagating recalcitrant blue spruce (Picea pungens) cultivar Hoopsii

This study demonstrates that somatic embryogenesis is a fast and prolific method for propagating the recalcitrant blue spruce cultivar Hoopsii, achieving 92.8% conversion of mature somatic embryos into plantlets.

Cyclin B3 is specifically required for metaphase to anaphase transition in mouse oocyte meiosis I

This study identifies Cyclin B3's specific role in facilitating metaphase-to-anaphase transition in mouse oocyte meiosis I, while showing it is not required for oocyte maturation or sister chromosome segregation.

Effects of CEPA and 1-MCP on flower bud differentiation of apple cv. ‘Nagafu No.2’ grafted on different rootstocks

This study examines the effects of CEPA and 1-MCP on flower bud differentiation in apple trees grafted on different rootstocks, finding CEPA promotes flowering while 1-MCP has no significant effect.