Author

S. Lienenklaus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

N. Sanders· 2 shared Z. Zhong· 2 shared A. Choi· 1 shared A. Garcia-Sastre· 1 shared A. Gerbaulet· 1 shared A. Prasse· 1 shared A. Roers· 1 shared A. Schambach· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

N. Sanders

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

cGAS/STING-DEPENDENT SENSING OF ENDOGENOUS RNA

T. Schumann, S. C. Ramon, N. Schubert, M. A. Mayo, M. Hega, S.-R. Ada, L. Sydow, M. Hajikazemi, Y. Ge, M. Badstübner, S. Lienenklaus, B. Utess, L. Muhandes, M. Haase, L. Müller, , R. Behrendt

The paper shows that loss of SAMHD1 leads to chronic DNA damage and cGAS/STING-dependent type I interferon production in mice, linking it to autoimmunity and cancer.

bioRxiv · May 16, 2022Immunology

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Modified Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine

S. Jangra, J. De Vrieze, A. Choi, R. Rathnasinghe, G. Laghlali, A. Uvyn, S. Van Herck, L. Nuhn, K. Deswarte, Z. Zhong, N. Sanders, S. Lienenklaus, S. David, S. Strohmeier, F. Amanat, , M. Schotsaert

This paper demonstrates that a novel TLR7/8 agonist adjuvant enables single-shot protection against SARS-CoV-2 and influenza in mice using recombinant spike protein and inactivated vaccines.

bioRxiv · Oct 23, 2020Microbiology

Airway Basal Cells show a dedifferentiated KRT17high Phenotype and promote Fibrosis in Idiopathic Pulmonary Fibrosis

B. Jaeger, J. C. Schupp, L. Plappert, O. Terwolbeck, G. Kayser, P. Engelhard, T. S. Adams, R. Zweigerdt, H. Kempf, S. Lienenklaus, W. Garrels, I. Nazarenko, D. Jonigk, M. Wygrecka, D. Klatt, , A. Prasse

This study identifies IPF-ABC as dedifferentiated KRT17high cells that promote fibrosis and shows SRC inhibition can reverse their profibrotic effects.

bioRxiv · Sep 4, 2020Cell Biology

Corticosteroids and cellulose purification improve respectively the in vivo translation and vaccination efficacy of self-amplifying mRNAs

Z. Zhong, S. Mc Cafferty, L. Opsomer, H. Wang, H. Huysmans, J. De Temmerman, S. Lienenklaus, J. P. Portela Catani, F. Combes, N. Sanders

This study shows that corticosteroids and cellulose purification enhance sa-mRNA translation and vaccination efficacy by reducing innate immune responses.

bioRxiv · Aug 26, 2020Immunology