K.-H. Kim

Loss-of-SIRT7 sensitizes hepatocellular carcinoma to sorafenib through the regulation of ERK Phosphorylation

This study shows that SIRT7 contributes to sorafenib resistance in HCC by enhancing ERK phosphorylation, and inhibiting SIRT7 with sorafenib reduces tumor growth.

Influenza virus-like particle-based hybrid vaccine containing RBD induces immunity against influenza and SARS-CoV-2 viruses

This study develops a hybrid vaccine combining influenza VLPs with SARS-CoV-2 RBD and GM-CSF, showing protection against both viruses in mice.

Highly efficient, all-organic bioluminescence-photosensitizer conjugate eradicates early-stagetumors and prevents metastasis in mice

This paper develops a bioluminescence-activated PDT system that eradicates tumors and prevents metastasis in mice by using efficient BRET conjugates and membrane-fusion liposomes.

Synthetic glabridin derivatives mitigate steatohepatitis in a diet-induced biopsy-confirmed non-alcoholic steatosis hepatitis mouse model through paraoxonase-2

This study shows synthetic glabridin derivatives reduce NASH symptoms in mice by activating autophagy and antioxidant defenses through targeting paraoxonase-2.

The first finding of lichen Solorina saccata at an algific talus slope in Korea

This study reports the first lichen ecology investigation at an algific talus slope in Korea, identifying 27 lichen species, including the newly recorded Solorina saccata, and predicts its potential habitats in South Korea.

Conversion of a soluble protein into a potent chaperone in vivo

This study shows a soluble protein can act as a chaperone in vivo, preventing protein aggregation and aiding folding, similar to known chaperones.