Author

T. Gallagher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 2 Biophysics· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

E. Qing· 3 shared A. J. Mulholland· 2 shared I. Bermudez· 2 shared R. B. Sessions· 2 shared A. A. Ibarra· 1 shared A. E. M. Blom· 1 shared A. E. Merrill· 1 shared A. K. Muthusamy· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

E. Qing

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning

R. Lei, E. Qing, A. Odle, M. Yuan, T. J. C. Tan, N. So, W. O. Ouyang, I. A. Wilson, T. Gallagher, S. Perlman, N. C. Wu, L. Y. R. Wong

This study uses deep mutational scanning to analyze the SARS-CoV-2 spike fusion peptide, identifying mutations affecting viral entry and antibody resistance.

bioRxiv · Nov 28, 2023Microbiology

A single C-terminal residue controls SARS-CoV-2 spike trafficking and virion assembly

D. Dey, E. Qing, Y. He, Y. Chen, B. Jennings, W. Cohn, S. Singh, L. Gakhar, N. J. Schnicker, B. G. Pierce, J. P. Whitelegge, B. Doray, J. P. Orban, T. Gallagher, S. S. Hasan

This study identifies a C-terminal residue critical for SARS-CoV-2 spike protein trafficking and virion assembly, offering insights for vaccine design.

bioRxiv · Mar 9, 2023 · PreprintBiophysics

Structural and temporal basis for agonism in the α4β2 nicotinic acetylcholine receptor

A. S. F. Oliveira, I. Bermudez, T. Gallagher, S. Wonnacott, G. Ciccotti, R. B. Sessions, A. J. Mulholland

This study uses molecular dynamics simulations to analyze how full and partial agonists induce different conformational changes in the α4β2 nicotinic acetylcholine receptor, affecting signal propagation.

bioRxiv · Feb 23, 2022 · PreprintBiochemistry

Fluorescence Activation Mechanism and Imaging of Drug Permeation with New Sensors for Smoking-Cessation Ligands

A. L. Nichols, Z. Blumenfeld, C. Fan, L. Luebbert, A. E. M. Blom, B. N. Cohen, J. S. Marvin, P. M. Borden, C. H. Kim, A. K. Muthusamy, A. V. Shivange, H. J. Knox, H. R. Campello, J. H. Wang, D. A. Dougherty, , H. A. Lester

The paper develops new fluorescent sensors to study the pharmacokinetics of nicotinic partial agonists in living cells and identifies differences in membrane crossing rates among these drugs.

bioRxiv · Oct 4, 2021Pharmacology & Toxicology

Limited variation between SARS-CoV-2-infected individuals in domain specificity and relative potency of the antibody response against the spike glycoprotein

H. A. Van Ert, D. W. Bohan, K. J. Rogers, M. Fili, A. R. Rojas Chavez, E. Qing, C. Han, S. M. Dempewolf, G. Hu, N. Schwery, K. M. Sevcik, N. Ruggio, D. Boyt, M. Pentella, T. Gallagher, , H. Haim

The paper analyzes antibody responses in SARS-CoV-2-infected individuals, finding limited variation in domain specificity and relative neutralization potency across subjects.

bioRxiv · Aug 4, 2021Microbiology

LY6E impairs coronavirus fusion and confers immune control of viral disease

S. Pfaender, K. B. Mar, E. Michailidis, A. Kratzel, D. Hirt, P. V'kovski, W. Fan, N. Ebert, H. Stalder, H. Kleine-Weber, M. Hoffmann, H. H. Hoffmann, M. Saeed, R. Dijkman, E. Steinmann, , V. Thiel

This study identifies LY6E as an interferon-induced gene that restricts coronavirus entry and pathogenesis by inhibiting spike protein-mediated fusion and protecting immune cells.

Nature Microbiology · Jul 23, 2020Peer-reviewedMicrobiology

Simulations support the interaction of the SARS-CoV-2 spike protein with nicotinic acetylcholine receptors

A. S. Oliveira, A. A. Ibarra, I. Bermudez, L. Casalino, Z. Gaieb, D. K. Shoemark, T. Gallagher, R. B. Sessions, R. E. Amaro, A. J. Mulholland

The paper uses molecular simulations to show that the SARS-CoV-2 spike protein's Y674-R685 loop binds to nicotinic acetylcholine receptors, with specific interactions and conformational changes observed across different receptor subtypes.

bioRxiv · Jul 16, 2020Biochemistry

HLA class II polymorphism influences the immune response to protective antigen and susceptibility to Bacillus anthracis

D. M. Altmann, S. Ascough, R. Ingram, K. Chu, S. Moore, T. Gallagher, H. Dyson, M. Doganay, G. Metan, Y. Ozkul, L. Baillie, E. D. Williamson, J. Robinson, B. Maillere, R. Boyton

This study identifies HLA class II polymorphism effects on CD4+ T cell responses to PA epitopes and susceptibility to Bacillus anthracis.

bioRxiv · Nov 13, 2019 · PreprintImmunology